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21 May 2007

Volume 90, Issue 21, Articles (21xxxx)

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Appl. Phys. Lett. 90, 213501 (2007); http://dx.doi.org/10.1063/1.2742294 (3 pages)

Jong-Hyun Ahn, Hoon-Sik Kim, Etienne Menard, Keon Jae Lee, Zhengtao Zhu, Dae-Hyeong Kim, Ralph G. Nuzzo, John A. Rogers, Islamshah Amlani, Vadim Kushner, Shawn G. Thomas, and Terrisa Duenas
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Analysis of structural changes in active site of luciferase adsorbed on nanofabricated hydrophilic Si surface by molecular-dynamics simulations

Katsuhiko Nishiyama and Tadatsugu Hoshino

Appl. Phys. Lett. 90, 213901 (2007); http://dx.doi.org/10.1063/1.2742912 (3 pages) | Cited 3 times

Online Publication Date: 23 May 2007

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Interactions between luciferase and a nanofabricated hydrophilic Si surface were explored by molecular-dynamics simulations. The structural changes in the active-site residues, the residues affecting the luciferin binding, and the residues affecting the bioluminescence color were smaller on the nanofabricated hydrophilic Si surface than on both a hydrophobic Si surface and a hydrophilic Si surface. The nanofabrication and wet-treatment techniques are expected to prevent the decrease in activity of luciferase on the Si surface.
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87.50.wj Dosimetry/exposure assessment
68.47.Fg Semiconductor surfaces
68.43.-h Chemisorption/physisorption: adsorbates on surfaces
87.15.M- Spectra of biomolecules

Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems

K. M. Reddy, Kevin Feris, Jason Bell, Denise G. Wingett, Cory Hanley, and Alex Punnoose

Appl. Phys. Lett. 90, 213902 (2007); http://dx.doi.org/10.1063/1.2742324 (3 pages) | Cited 68 times

Online Publication Date: 24 May 2007

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We report on the toxicity of ZnO nanoparticles (NPs) to gram-negative and gram-positive bacterial systems, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and primary human immune cells. ZnO NP ( ∼ 13 nm) showed complete inhibition of E. coli growth at concentrations ≥ 3.4 mM, whereas growth of S. aureus was completely inhibited for ≥ 1 mM. Parallel experiments using flow cytometry based assays clearly demonstrated that growth inhibitory properties of ZnO NP were accompanied by a corresponding loss of cell viability. Identical ZnO NP had minimal effects on primary human T cell viability at concentrations toxic to both gram-negative and gram-positive bacteria. Collectively, these experiments demonstrate selectivity in the toxic nature of ZnO NP to different bacterial systems and human T lymphocytes. Developing selective toxicity to biological systems and controlling it by NP design could lead to biomedical and antibacterial applications.
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87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
87.85.J- Biomaterials
87.17.-d Cell processes
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