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28 May 2007

Volume 90, Issue 22, Articles (22xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 90, 221101 (2007); http://dx.doi.org/10.1063/1.2743884 (3 pages)

Siyka I. Shopova, Hongying Zhou, Xudong Fan, and Po Zhang
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Photoacoustic imaging of early inflammatory response using gold nanorods

Kang Kim, Sheng-Wen Huang, Shai Ashkenazi, Matthew O’Donnell, Ashish Agarwal, Nicholas A. Kotov, Michael F. Denny, and Mariana J. Kaplan

Appl. Phys. Lett. 90, 223901 (2007); http://dx.doi.org/10.1063/1.2743752 (3 pages) | Cited 45 times

Online Publication Date: 29 May 2007

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Gold nanorods have unusually strong absorption in near infrared, which can be utilized for an optical imaging with nanocolloids. The feasibility of photoacoustic imaging of inflammatory responses using bioconjugated gold nanorods is demonstrated. To target the stimulated cells, gold nanorods were conjugated to anti-intercellular adhesion molecule-1 (ICAM-1) which binds to cell surfaces over expressing ICAM-1. A monolayer of stimulated endothelial cells labeled with bioconjugated gold nanorods was scanned using a high frequency transducer. Photoacoustic images differentiated inflamed cells from control cells and matched well with fluorescence images. This technology may permit identification of critical inflammation sites such as blood vessels.
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87.63.D- Ultrasonography
43.80.Qf Medical diagnosis with acoustics
43.80.Vj Acoustical medical instrumentation and measurement techniques
87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
87.63.L- Visual imaging
43.35.Ud Thermoacoustics, high temperature acoustics, photoacoustic effect
87.16.-b Subcellular structure and processes
87.19.U- Hemodynamics
87.19.Wx Pneumodyamics, respiration

Dielectrophoretic tweezers for examining particle-surface interactions within microfluidic devices

Sang Woo Lee, Haibo Li, and Rashid Bashir

Appl. Phys. Lett. 90, 223902 (2007); http://dx.doi.org/10.1063/1.2744483 (3 pages) | Cited 3 times

Online Publication Date: 30 May 2007

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The authors present dielectrophoresis (DEP)-based tweezers that can be used to characterize the interactions between a particle and the surface it is attached to, within a microfluidic device. As a proof of concept, 5.4 μm polystyrene beads functionalized by carboxyl group were attached on a bare and poly-L-lysine functionalized oxide surface. Negative dielectrophoresis force was generated using interdigitated electrodes and the peak dielectrophoresis voltage where the beads were repelled away from the surface was used to characterize the strength of interaction between the particle and the surface. Electric field and DEP force calculation were used to corroborate the measured results.
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82.45.Fk Electrodes
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid

Tae Yun Kwon, Kilho Eom, Jae Hong Park, Dae Sung Yoon, Tae Song Kim, and Hong Lim Lee

Appl. Phys. Lett. 90, 223903 (2007); http://dx.doi.org/10.1063/1.2741053 (3 pages) | Cited 25 times

Online Publication Date: 1 June 2007

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The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q = 15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.
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87.80.-y Biophysical techniques (research methods)
87.15.R- Reactions and kinetics
87.14.E- Proteins
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
85.50.-n Dielectric, ferroelectric, and piezoelectric devices

Organosilane-functionalized wide band gap semiconductor surfaces

R. M. Petoral, Jr., G. R. Yazdi, A. Lloyd Spetz, R. Yakimova, and K. Uvdal

Appl. Phys. Lett. 90, 223904 (2007); http://dx.doi.org/10.1063/1.2745641 (3 pages) | Cited 11 times

Online Publication Date: 1 June 2007

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Surface functionalization of wide band gap semiconductors, SiC, ZnO, and GaN, with organosilane is reported. Formation of self-assembled monolayers of mercaptopropyltrimethoxysilane is confirmed by x-ray photoelectron spectroscopy and atomic force microscopy. The molecules are adsorbed on the surfaces through the silane groups with the free thiol groups molecularly oriented away from the surface. Moreover, chemisorption via the thiolate is observed for the ZnO surface. Immobilization of a model biomolecule to the functionalized surface is demonstrated. An amino acid derivative, i.e., phosphotyrosine derived thiol, is linked on the functionalized ZnO and GaN surfaces via formation of disulfide bridges.
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68.43.Mn Adsorption kinetics
68.47.Pe Langmuir-Blodgett films on solids; polymers on surfaces; biological molecules on surfaces
87.15.-v Biomolecules: structure and physical properties
87.85.J- Biomaterials
79.60.Dp Adsorbed layers and thin films
68.37.Ps Atomic force microscopy (AFM)
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