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15 Jan 2007

Volume 90, Issue 3, Articles (03xxxx)

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Appl. Phys. Lett. 90, 032108 (2007); http://dx.doi.org/10.1063/1.2431702 (3 pages)

D. Buca, B. Holländer, S. Feste, St. Lenk, H. Trinkaus, S. Mantl, R. Loo, and M. Caymax
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Self-assembly of vesicle nanoarrays on Si: A potential route to high-density functional protein arrays

C. S. Ramanujan, K. Sumitomo, M. R. R. de Planque, H. Hibino, K. Torimitsu, and J. F. Ryan

Appl. Phys. Lett. 90, 033901 (2007); http://dx.doi.org/10.1063/1.2431774 (3 pages) | Cited 3 times

Online Publication Date: 17 January 2007

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The authors show that 100 nm unilamellar thiol-tagged vesicles bind discretely and specifically to Au nanodots formed on a Si surface. An array of such dots, consisting of 20 nm Au–Si three-dimensional islands, is formed by self-assembly on terraces of small-angle-miscut Si(111) after Au deposition. Consequently, both the formation of the nanopattern and the subsequent attachment of the vesicles are self-organized and occur without the need for any “top-down” lithographic processes. This approach has the potential to provide the basis of a low-cost, high-density nanoarray for use in proteomics and drug discovery.
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87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
87.14.E- Proteins
87.14.Cc Lipids
87.16.D- Membranes, bilayers, and vesicles
81.16.Dn Self-assembly

Infrared scanning near-field optical microscopy observation of low-frequency electromagnetic field effects on functional groups in eukaryotic cells

A. Cricenti, R. Generosi, M. Luce, F. Ronci, P. Perfetti, D. Vobornik, G. Margaritondo, J. S. Sanghera, I. D. Aggarwal, N. H. Tolk, D. W. Piston, S. Grimaldi, A. Lisi, and S. Rieti

Appl. Phys. Lett. 90, 033902 (2007); http://dx.doi.org/10.1063/1.2432231 (3 pages) | Cited 4 times

Online Publication Date: 17 January 2007

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The authors observed changes in the biochemical properties of eukaryotic cells exposed to an ac magnetic field by infrared scanning near-field optical microscopy. They specifically investigated the changes in the distribution of the inner chemical functional groups and in the cell morphology induced by a 24 h exposure to a 1 mT (rms), 50 Hz sinusoidal magnetic field in a temperature-regulated solenoid. These results accentuate the crucial questions—raised by several recent studies—about the impact of low-frequency electromagnetic field on human cells.
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87.50.C- Static and low-frequency electric and magnetic fields effects
87.17.-d Cell processes
87.15.N- Properties of solutions of macromolecules
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