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Applied Physics Letters / Volume 91 / Issue 11 / APPLIED BIOPHYSICS

Appl. Phys. Lett. 91, 113903 (2007); http://dx.doi.org/10.1063/1.2783213 (3 pages)

Phase interrogation of localized surface plasmon resonance biosensors based on electro-optic modulation

Tzyy-Jiann Wang and Chih-Wei Hsieh

Institute of Electro-Optical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan

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(Received 19 June 2007; accepted 17 August 2007; published online 11 September 2007)

A resolution-tunable localized surface plasmon resonance (LSPR) biosensor employing electro-optically modulated phase interrogation is presented. This biosensor modulates the analyte-dependent LSPR phase characteristic through electro-optic effect by varying the wave vector of lightwave for exciting surface plasmon. The induced LSPR phase change is measured by the collinear heterodyne technique and its relation with the applied voltage is utilized to determine the analyte concentration. Experimental results show that the regression slope of the phase-voltage relation decreases with the analyte concentration and the detection sensitivity can be increased by widening the waveguide width and using thinner gold film beneath gold nanoparticles. Detection resolution of this LSPR biosensor can be enhanced by increasing the applied voltage to enlarge the induced phase change. The presented LSPR biosensor employing phase interrogation has the features of resolution tunability, fast modulation speed, high modulation stability, and noise reduction.

© 2007 American Institute of Physics

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KEYWORDS and PACS

Keywords

biosensors, electro-optical modulation, gold, integrated optics, localised states, nanoparticles, optical films, optical noise, optical sensors, optical waveguides, regression analysis, sensitivity, surface plasmon resonance

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 07.07.Df

    Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

  • 42.79.Hp

    Optical processors, correlators, and modulators

  • 42.82.Et

    Waveguides, couplers, and arrays

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2783213

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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