APL Nameplate
  • Volume/Page
  • Keyword
  • DOI
  • Citation
  • Advanced
   
 
 
 

Flickr Twitter iResearch App Facebook

BROWSE VOLUMES

Year Range: 
Search Issue | RSS Feeds RSS
Previous Issue Next Issue

17 Sep 2007

Volume 91, Issue 12, Articles (12xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 91, 123101 (2007); http://dx.doi.org/10.1063/1.2784389 (3 pages)

Thierry Laroche, Alexandre Vial, and Matthieu Roussey
Enlarge Image | Read More
Return to All Sections
back to top
RSS Feeds

Hourglass-shaped aperture for cellular electrophysiological study

Chang-Yu Chen, Kuan-Ting Liu, De-Shien Jong, and Andrew M. Wo

Appl. Phys. Lett. 91, 123901 (2007); http://dx.doi.org/10.1063/1.2783192 (3 pages) | Cited 4 times

Online Publication Date: 17 September 2007

Full Text: Read Online (HTML) | Download PDF

Show Abstract
This work presents a simple process of reflow of melted glass by CO2 laser to form an hourglass-shaped aperture for cellular electrophysiological study. The fabricated aperture proves to be smooth, circular, debris-free, and freshly activated. Two-phase flow simulation illuminates details of the reflow process. The resulting seal resistance quality is well suited to measure ion-channel activities; a seal resistance of 1.9 GΩ for PC-12 cell and a typical resistance of 200 MΩ for Chinese hamster ovary cells were achieved. This approach can be integrated with microfluidics in a single cell patch or array configuration.
Show PACS
87.19.R- Mechanical and electrical properties of tissues and organs
47.85.-g Applied fluid mechanics
87.16.Uv Active transport processes
Return to All Sections
Close

Google Calendar

ADVERTISEMENT

Go to AIP Home   © AIP Publishing LLC
close