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29 Oct 2007

Volume 91, Issue 18, Articles (18xxxx)

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Appl. Phys. Lett. 91, 183501 (2007); http://dx.doi.org/10.1063/1.2801554 (3 pages)

Aurelien Du Pasquier, Daniel D. T. Mastrogiovanni, Lauren A. Klein, Tong Wang, and Eric Garfunkel
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An anomalous subdiffusion model for calcium spark in cardiac myocytes

Wenchang Tan, Chaoqi Fu, Ceji Fu, Wenjun Xie, and Heping Cheng

Appl. Phys. Lett. 91, 183901 (2007); http://dx.doi.org/10.1063/1.2805208 (3 pages) | Cited 19 times

Online Publication Date: 31 October 2007

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The elementary events of excitation-contraction coupling in heart muscle are Ca2+ sparks, which arise from ryanodine receptors in the sarcoplasmic reticulum (SR). Here, an anomalous subdiffusion model is developed to explore Ca2+ spark formation in cardiac myocytes. Numerical simulations reproduce the brightness, the time course, and spatial size of a typical cardiac Ca2+ spark. It is suggested that the diffusion of Ca2+ spark in the cytoplasm may no longer obey Fickian second law, but the anomalous space subdiffusion. The physical reason is perhaps due to the effects of the electric field of the calcium ions and the viscoelasticity of the cytoplasm and its complex structures.
Show PACS
87.16.Uv Active transport processes
87.16.D- Membranes, bilayers, and vesicles
87.19.Ff Muscles
87.19.Hh Cardiac dynamics
87.19.R- Mechanical and electrical properties of tissues and organs
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