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5 Nov 2007

Volume 91, Issue 19, Articles (19xxxx)

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Appl. Phys. Lett. 91, 191106 (2007); http://dx.doi.org/10.1063/1.2804016 (3 pages)

A. Pikulin, N. Bityurin, G. Langer, D. Brodoceanu, and D. Bäuerle
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Ultrasound surgery with a toric transducer allows the treatment of large volumes over short periods of time

David Melodelima, William A. N’Djin, Hubert Parmentier, Sabrina Chesnais, Michel Rivoire, and Jean-Yves Chapelon

Appl. Phys. Lett. 91, 193901 (2007); http://dx.doi.org/10.1063/1.2805113 (3 pages) | Cited 10 times

Online Publication Date: 5 November 2007

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Thermal ablation by physical agents is widely used in clinical settings, but it generally results in a small coagulated volume. Here, we report that a technologically advanced high intensity focused ultrasound transducer can significantly enlarge the coagulated volume over short periods of time. Eight ultrasound emitters were created by sectioning a single toric piezocomposite transducer. A single thermal lesion is created when the eight emitters perform alternative and consecutive 5 s ultrasound exposures. This paper presents in vivo evidence that the coagulated volume obtained from a 40 s total exposure in the liver was 8.6±4.8 cm3.
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43.38.-p Transduction; acoustical devices for the generation and reproduction of sound
87.80.-y Biophysical techniques (research methods)
87.50.Y- Biological effects of acoustic and ultrasonic energy
87.50.yt Therapeutic applications

Mass-based readout for agglutination assays

Rumi Chunara, Michel Godin, Scott M. Knudsen, and Scott R. Manalis

Appl. Phys. Lett. 91, 193902 (2007); http://dx.doi.org/10.1063/1.2806197 (3 pages) | Cited 3 times

Online Publication Date: 6 November 2007

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We present a mass-based readout for agglutination assays. The suspended microchannel resonator (SMR) is used to classify monomers and dimers that are formed during early stage aggregation, and to relate the total count to the analyte concentration. Using a model system of streptavidin functionalized microspheres and biotinylated antibody as the analyte, we obtain a dose-response curve over a concentration range of 0.63–630 nM and show that the results are comparable to what has been previously achieved by image analysis and conventional flow cytometry.
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07.10.Cm Micromechanical devices and systems
47.60.-i Flow phenomena in quasi-one-dimensional systems
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