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Applied Physics Letters / Volume 91 / Issue 20 / DEVICE PHYSICS

Appl. Phys. Lett. 91, 203511 (2007); http://dx.doi.org/10.1063/1.2814031 (3 pages)

Zone sculpting using partitioned electrokinetic injections

Max Narovlyansky1, George M. Whitesides1, and Todd M. Squires2

1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA
2Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA

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(Received 14 September 2007; accepted 22 October 2007; published online 14 November 2007)

We describe a general and versatile method to sculpt low-dispersion, high-fidelity sample zones in microfluidic devices for high resolution electrokinetic separations. In a simple channel intersection, microfabricated partitions reduce each channel’s permittivity to transverse electric fields, yet maintain their permeability to parallel fields. The resulting anisotropy effectively confines fields to the intersection, thus sculpting the injected plug. We demonstrate by injecting narrow yet symmetric sample zones in a poly(dimethylsiloxane) microfluidic device. This simple geometric strategy for sculpting the field and flow lines does not depend on the device material or analyte/electrolyte properties, and is limited in scale only by fabrication capabilities.

© 2007 American Institute of Physics

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KEYWORDS and PACS

Keywords

electrokinetic effects, electrophoresis, microchannel flow, organic compounds, permittivity

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2814031

PUBLICATION DATA

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0003-6951 (print)  
1077-3118 (online)

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$abstract.society.value is a Member of CrossRef American Institute of Physics

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