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24 Dec 2007

Volume 91, Issue 26, Articles (26xxxx)

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Appl. Phys. Lett. 91, 261106 (2007); http://dx.doi.org/10.1063/1.2825578 (3 pages)

W. M. Zhu, T. Zhong, A. Q. Liu, X. M. Zhang, and M. Yu
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Laser Doppler flowmetry signals to quantify effects of isoflurane on the peripheral cardiovascular system of healthy rats

Anne Humeau, Lionel Fizanne, Jérôme Roux, Pierre Asfar, Paul Cales, David Rousseau, and François Chapeau-Blondeau

Appl. Phys. Lett. 91, 263901 (2007); http://dx.doi.org/10.1063/1.2825585 (3 pages)

Online Publication Date: 27 December 2007

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The optical Doppler effect resulting from interactions between laser light photons and red blood cells of the microcirculation is used to characterize the influence of isoflurane, an halogenated volatile anesthetic, on the peripheral cardiovascular system. After having recorded laser Doppler flowmetry blood perfusion signals on isoflurane-induced anesthetized healthy rats, wavelet analyses show a significant decrease of the myogenic and neurogenic activities when isoflurane dose increases from 1.5% to 3%. Moreover, the approximate entropy shows a weak decrease of signal irregularity when dose of isoflurane increases. These findings demonstrate the usefulness of the optical Doppler effect in physiological and pharmacological applications.
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42.62.Be Biological and medical applications

Protein-based biomemory device consisting of the cysteine-modified azurin

Jeong-Woo Choi, Byung-Keun Oh, Young Jun Kim, and Junhong Min

Appl. Phys. Lett. 91, 263902 (2007); http://dx.doi.org/10.1063/1.2828046 (3 pages) | Cited 11 times

Online Publication Date: 27 December 2007

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We demonstrated a protein-based memory device using recombinant Pseudomonas aeruginosa azurin (azurin), a metalloprotein with a redox property. Azurin was recombined with a cysteine residue to enhance the stability of the self-assembled protein on the gold surface. The memory device characteristics, including the “read,” “write,” and “erase” functions of the self-assembled azurin layer, were well demonstrated with three distinct electrical states of azurin layers by cyclic voltammetry. The robustness of the protein-based biomemory device was validated by the repeated electrochemical performance of 500 000 cycles.
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85.65.+h Molecular electronic devices
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