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6 Aug 2007

Volume 91, Issue 6, Articles (06xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 91, 063118 (2007); http://dx.doi.org/10.1063/1.2768861 (3 pages)

Douglas C. Meier, Steve Semancik, Bradley Button, Evgheni Strelcov, and Andrei Kolmakov
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Cholesterol biosensor based on rf sputtered zinc oxide nanoporous thin film

S. P. Singh, Sunil K. Arya, Pratibha Pandey, B. D. Malhotra, Shibu Saha, K. Sreenivas, and Vinay Gupta

Appl. Phys. Lett. 91, 063901 (2007); http://dx.doi.org/10.1063/1.2768302 (3 pages) | Cited 48 times

Online Publication Date: 9 August 2007

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Cholesterol oxidase (ChOx) has been immobilized onto zinc oxide (ZnO) nanoporous thin films grown on gold surface. A preferred c-axis oriented ZnO thin film with porous surface morphology has been fabricated by rf sputtering under high pressure. Optical studies and cyclic voltammetric measurements show that the ChOx/ZnO/Au bioelectrode is sensitive to the detection of cholesterol in 25–400 mg/dl range. A relatively low value of enzyme’s kinetic parameter (Michaelis-Menten constant) ∼ 2.1 mM indicates enhanced enzyme affinity of ChOx to cholesterol. The observed results show promising application of nanoporous ZnO thin film for biosensing application without any functionalization.
Show PACS
87.80.-y Biophysical techniques (research methods)
87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
87.14.E- Proteins
81.15.Cd Deposition by sputtering
78.66.Hf II-VI semiconductors
82.80.Fk Electrochemical methods
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