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20 Aug 2007

Volume 91, Issue 8, Articles (08xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 91, 083504 (2007); http://dx.doi.org/10.1063/1.2772752 (3 pages)

Jeong-M. Choi, Jae Hoon Kim, and Seongil Im
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Sensor-integrated fluorescent microarray for ultrahigh sensitivity direct-imaging bioassays: Role of a high rejection of excitation light

Lucio Martinelli, Houtai Choumane, Khoi-Nguyen Ha, Gabriel Sagarzazu, Carole Goutel, Claude Weisbuch, Thierry Gacoin, and Henri Benisty

Appl. Phys. Lett. 91, 083901 (2007); http://dx.doi.org/10.1063/1.2767209 (3 pages) | Cited 5 times

Online Publication Date: 20 August 2007

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Fluorescent microarrays exploit fluorescent labeled targets bound to immobilized biomolecular probes. Their signal-to-noise ratio is limited by the collection aperture in common confocal geometries. Taking advantage of a very high rejection filter deposited onto a silicon arrayed detector (coupled-charge device or complementary metal-oxide semiconductor), it is demonstrated that a highly compact lens-free assay with photon collection of order unity operates with a 30-fold improvement over a conventional (substrate + free-space optics) scheme. Through analysis of improvements over the present demonstrator, a single molecule per pixel sensitivity is predicted.
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87.80.-y Biophysical techniques (research methods)
87.14.-g Biomolecules: types
42.79.Pw Imaging detectors and sensors
87.63.L- Visual imaging

High density single molecule surface patterning with colloidal epitaxy

Jerrod J. Schwartz and Stephen R. Quake

Appl. Phys. Lett. 91, 083902 (2007); http://dx.doi.org/10.1063/1.2772762 (3 pages) | Cited 2 times

Online Publication Date: 21 August 2007

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Simple and inexpensive methods for dense surface patterning of single molecules will help realize the massive potential throughput of molecular arrays in biology and nanoscience. To surpass the resolvable density limit imposed by random deposition, the authors have developed a method that uses colloids to pattern single molecules at a fixed length scale. They demonstrate the ability to pattern fluorescently labeled DNA such that ∼ 38% of the available diffraction-limited regions contain exactly one molecule. This density is slightly less than the theoretical limit suggested by Monte Carlo simulations but surpasses the random deposition limit by more than threefold.
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87.80.-y Biophysical techniques (research methods)
87.14.G- Nucleic acids
82.70.Dd Colloids
02.70.Uu Applications of Monte Carlo methods

Magnetoacoustic tomographic imaging of electrical impedance with magnetic induction

Rongmin Xia, Xu Li, and Bin He

Appl. Phys. Lett. 91, 083903 (2007); http://dx.doi.org/10.1063/1.2772763 (3 pages) | Cited 18 times

Online Publication Date: 22 August 2007

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Magnetoacoustic tomography with magnetic induction (MAT-MI) is a recently introduced method for imaging tissue electrical impedance properties by integrating magnetic induction and ultrasound measurements. In the present study, the authors have developed a focused cylindrical scanning mode MAT-MI system and the corresponding reconstruction algorithms. Using this system, they demonstrated a three-dimensional MAT-MI imaging approach in a physical phantom, with cylindrical scanning combined with ultrasound focusing, and the ability of MAT-MI in imaging electrical conductivity properties of biological tissue.
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87.63.D- Ultrasonography
87.50.C- Static and low-frequency electric and magnetic fields effects
87.57.N- Image analysis
43.80.Qf Medical diagnosis with acoustics
43.60.Rw Remote sensing methods, acoustic tomography
43.35.Wa Biological effects of ultrasound, ultrasonic tomography

Mechanism and sensitivity of the intrinsic charge detection of biomolecular interactions by field effect devices

B. K. Wunderlich, P. A. Neff, and A. R. Bausch

Appl. Phys. Lett. 91, 083904 (2007); http://dx.doi.org/10.1063/1.2775040 (3 pages) | Cited 8 times

Online Publication Date: 24 August 2007

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For many biotechnological applications a quantitative and label-free detection of biomolecular interactions is becoming of outstanding importance. The here presented analytical description of the direct charge detection by field effect devices introduces a straightforward tool for quantitative analysis. By combined measurements of the pH and electrolyte concentration response the absolute amount of adsorbed surface charge can now be determined.
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87.80.-y Biophysical techniques (research methods)
85.30.Tv Field effect devices
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