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9 Jun 2008

Volume 92, Issue 23, Articles (23xxxx)

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Appl. Phys. Lett. 92, 231901 (2008); http://dx.doi.org/10.1063/1.2938921 (3 pages)

N. A. Mara, D. Bhattacharyya, P. Dickerson, R. G. Hoagland, and A. Misra
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Cell compressibility studies utilizing noncontact hydrostatic pressure measurements on single living cells in a microchamber

L. A. G. Lin, A. Q. Liu, Y. F. Yu, C. Zhang, C. S. Lim, S. H. Ng, P. H. Yap, and H. J. Gao

Appl. Phys. Lett. 92, 233901 (2008); http://dx.doi.org/10.1063/1.2928229 (3 pages) | Cited 5 times

Online Publication Date: 11 June 2008

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A micro-optical-fluidic system (MOFS), which integrates a force generating device and an optical detector, is designed to measure the bulk modulus of a single living cell in real time under a controlled hydrostatic pressure. In this design, the accuracy of the bulk modulus measurement is improved because neither the force generating device nor the optical detector needs to be in contact with the cells. The MOFS device has been used to investigate the mechanotransduction of THP-1 human acute monocytic leukemia cells and the effects of the toxin lipopolysaccharide and colchicine on various properties of these cells.
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87.17.Rt Cell adhesion and cell mechanics
87.80.Ek Mechanical and micromechanical techniques

Effects of hydration on the mechanical response of individual collagen fibrils

Colin A. Grant, David J. Brockwell, Sheena E. Radford, and Neil H. Thomson

Appl. Phys. Lett. 92, 233902 (2008); http://dx.doi.org/10.1063/1.2937001 (3 pages) | Cited 14 times

Online Publication Date: 12 June 2008

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Collagen fibrils prepared from bovine Achilles tendon have been mechanically tested through nanoindentation by an atomic force microscope using force volume analysis. In ambient conditions where the fibrils are expected to be dehydrated, the elastic modulus was determined to be 1.9±0.5 GPa, while under aqueous fluid, it decreased by three orders of magnitude to 1.2±0.1 MPa. In air, fibril fracture occurred along the axis and the crack lengths were quantized to the D-banding periodicity. The apparent hardness of the fibrils was estimated to be in the range of 0.35–0.6 GPa.
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87.19.rd Elastic properties
87.19.rh Fluid transport and rheology
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