APL Nameplate
  • Volume/Page
  • Keyword
  • DOI
  • Citation
  • Advanced
   
 
 
 

Flickr Twitter iResearch App Facebook

BROWSE VOLUMES

Year Range: 
Search Issue | RSS Feeds RSS
Previous Issue Next Issue

23 Jun 2008

Volume 92, Issue 25, Articles (25xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 92, 254102 (2008); http://dx.doi.org/10.1063/1.2945893 (3 pages)

M. Trinker, S. Groth, S. Haslinger, S. Manz, T. Betz, S. Schneider, I. Bar-Joseph, T. Schumm, and J. Schmiedmayer
Enlarge Image | Read More
Return to All Sections
back to top
RSS Feeds

Effect of screening on the sensitivity of field-effect devices used to detect oligonucleotides

D. Landheer, W. R. McKinnon, W. H. Jiang, and G. Aers

Appl. Phys. Lett. 92, 253901 (2008); http://dx.doi.org/10.1063/1.2948906 (3 pages) | Cited 2 times

Online Publication Date: 23 June 2008

Full Text: Read Online (HTML) | Download PDF

Show Abstract
The effect of screening and the establishment of the Donnan potential at the floating gate of field-effect transistors (BioFETs) are calculated for a model that includes proton site binding on metal oxides used as gate insulators. Variations of response with pH, electrolyte concentration, and the fixed charge density of oligonucleotides are calculated assuming the charge is distributed homogenously in an ion-permeable membrane of finite thickness. Derived expressions describe the change in threshold voltage with electrolyte concentration and pH. These could be used to predict the sensitivity of the BioFET to hybridization, and provide a means of calibration prior to use.
Show PACS
85.30.Tv Field effect devices
87.80.-y Biophysical techniques (research methods)
Return to All Sections
Close

Google Calendar

ADVERTISEMENT

Go to AIP Home   © AIP Publishing LLC
close