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4 Feb 2008

Volume 92, Issue 5, Articles (05xxxx)

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Appl. Phys. Lett. 92, 053301 (2008); http://dx.doi.org/10.1063/1.2838457 (3 pages)

Michael S. Arnold, Gregory J. McGraw, Stephen R. Forrest, and Richard R. Lunt
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Magnetophoresis of flexible DNA-based dumbbell structures

B. Babić, R. Ghai, and K. Dimitrov

Appl. Phys. Lett. 92, 053901 (2008); http://dx.doi.org/10.1063/1.2834698 (3 pages) | Cited 3 times

Online Publication Date: 7 February 2008

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Controlled movement and manipulation of magnetic micro- and nanostructures using magnetic forces can give rise to important applications in biomedecine, diagnostics, and immunology. We report controlled magnetophoresis and stretching, in aqueous solution, of a DNA-based dumbbell structure containing magnetic and diamagnetic microspheres. The velocity and stretching of the dumbbell were experimentally measured and correlated with a theoretical model based on the forces acting on individual magnetic beads or the entire dumbbell structures. The results show that precise and predictable manipulation of dumbbell structures is achievable and can potentially be applied to immunomagnetic cell separators.
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87.15.B- Structure of biomolecules
87.14.gk DNA
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