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Applied Physics Letters / Volume 94 / Issue 11 / LASERS, OPTICS, AND OPTOELECTRONICS

Appl. Phys. Lett. 94, 111102 (2009); http://dx.doi.org/10.1063/1.3097008 (3 pages)

A wireless-compatible optics-free fluorescent array reader

M. Anwar1,2, T. Aytur3, and P. Matsudaira1

1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
3Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA

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(Received 16 November 2008; accepted 25 January 2009; published online 16 March 2009)

Optical-based bioassays, particularly fluorescent-based arrays, form the basis for biological detection in both biological and clinical assays, yet their use is restricted by the need for sensitive optical detectors and optics. To address this, we developed an integrated circuit-based fluorescent imaging platform that functions without the use of optics while directly integrating electronics, enabling a low-cost integrated solution. Additionally, we incorporate a wireless interface, enabling optical detection within any biological environment. As a proof of concept, we demonstrate the detection of 20 nM of Streptavidin on an array without the use of optical filters and lenses.

© 2009 American Institute of Physics

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KEYWORDS and PACS

Keywords

biological techniques, fluorescence, optical sensors, proteins

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 42.79.Pw

    Imaging detectors and sensors

  • 07.07.Df

    Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3097008

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    P. A. Besse, G. Boero, M. Demierre, V. Pott, and R. S. Popovic, Appl. Phys. Lett. 80, 4199 (2002)APPLAB000080000022004199000001.


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