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12 Oct 2009

Volume 95, Issue 15, Articles (15xxxx)

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Appl. Phys. Lett. 95, 153101 (2009); http://dx.doi.org/10.1063/1.3244597 (3 pages)

Geunjae Kwak, Mikyung Lee, Karuppanan Senthil, and Kijung Yong
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High spatial resolution single multiwalled carbon nanotube electrode for stimulation, recording, and whole cell voltage clamping of electrically active cells

Edward D. de Asis, Jr., Joseph Leung, Sally Wood, and Cattien V. Nguyen

Appl. Phys. Lett. 95, 153701 (2009); http://dx.doi.org/10.1063/1.3247885 (3 pages) | Cited 8 times

Online Publication Date: 13 October 2009

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We report the stimulation, recording, and voltage clamp of muscle fibers using a 30 nm diameter single multiwalled carbon nanotube electrode (sMWNT electrode) tip. Because of the lower access resistance, the sMWNT electrode conducts extracellular and intracellular stimulation more efficiently compared to glass micropipettes. The sMWNT electrode records field potentials and action potentials and performs whole cell voltage clamping of single fibers.
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87.85.eg Electrode stimulation
87.19.Ff Muscles
87.19.R- Mechanical and electrical properties of tissues and organs
87.17.-d Cell processes

Self-assembly of cholesterol DNA at liquid crystal/aqueous interface and its application for DNA detection

Siok Lian Lai, Deny Hartono, and Kun-Lin Yang

Appl. Phys. Lett. 95, 153702 (2009); http://dx.doi.org/10.1063/1.3247895 (3 pages) | Cited 5 times

Online Publication Date: 16 October 2009

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In this letter, we report a strategy of detecting the DNA targets by using a thin layer of self-assembled cholesterol-labeled DNA probes at the liquid crystal (LC)/aqueous interface. When the system is exposed to 51 μg/ml of complementary DNA targets, the optical appearance of LC shows a continuous change from dark to bright under the crossed polars within 15 min. No obvious change can be observed when the system is exposed to one or two base-pair mismatch DNA targets. This system provides a principle for label-free and real-time detection of DNA targets without any fluorescent labeling.
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87.85.fk Biosensors
87.15.H- Dynamics of biomolecules
87.14.gk DNA
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