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23 Nov 2009

Volume 95, Issue 21, Articles (21xxxx)

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Appl. Phys. Lett. 95, 213501 (2009); http://dx.doi.org/10.1063/1.3265958 (3 pages)

S. Cibella, M. Ortolani, R. Leoni, G. Torrioli, L. Mahler, Ji-Hua Xu, A. Tredicucci, H. E. Beere, and D. A. Ritchie
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Quantification of biomolecule agglutination by magnetorelaxometry

D. Eberbeck, F. Wiekhorst, U. Steinhoff, and L. Trahms

Appl. Phys. Lett. 95, 213701 (2009); http://dx.doi.org/10.1063/1.3267054 (3 pages) | Cited 4 times

Online Publication Date: 25 November 2009

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The agglutination of probes, i.e., biomolecules labeled by magnetic nanoparticles, due to their binding to complement analyte molecules (e.g., biomolecules) was quantified by magnetorelaxometry in terms of the mean and the width of the size distribution of the formed aggregates. We observed a clear maximum of the agglutination at a specific analyte-to-probe concentration ratio. By means of controlled variation of this ratio, the concentration of an analyte in solution can be measured in turbid media by two step preparation using magnetic measurement techniques without the need of a solid phase for immobilization of analyte or probe.
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87.80.-y Biophysical techniques (research methods)
87.15.nr Aggregation
87.50.cf Biophysical mechanisms of interaction
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