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27 Jul 2009

Volume 95, Issue 4, Articles (04xxxx)

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Appl. Phys. Lett. 95, 043110 (2009); http://dx.doi.org/10.1063/1.3184784 (3 pages)

Felix Loske and Angelika Kühnle
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Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles

Liyuan Ma, Yan Hong, Zeyu Ma, Charalambos Kaittanis, J. Manuel Perez, and Ming Su

Appl. Phys. Lett. 95, 043701 (2009); http://dx.doi.org/10.1063/1.3189082 (3 pages) | Cited 5 times

Online Publication Date: 27 July 2009

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We describe a multiplexed highly sensitive method to detect cancer biomarkers using silica encapsulated phase change nanoparticles as thermal barcodes. During phase changes, nanoparticles absorb heat energy without much temperature rise and show sharp melting peaks (0.6 °C). A series of phase change nanoparticles of metals or alloys can be synthesized in such a way that they melt between 100 and 700 °C, thus the multiplicity could reach 1000. The method has high sensitivity (8 nM) that can be enhanced using materials with large latent heat, nanoparticles with large diameter, or reducing the grafting density of biomolecules on nanoparticles.
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87.85.Rs Nanotechnologies-applications
81.16.-c Methods of micro- and nanofabrication and processing
87.15.K- Molecular interactions; membrane-protein interactions
87.19.xj Cancer

Polyethylcyanoacrylate nanoparticle transport through the stratum corneum

Roberto Díaz-Torres, Sergio J. Jiménez Sandoval, Oscar Ibañez-Orozco, and Suemi Rodríguez-Romo

Appl. Phys. Lett. 95, 043702 (2009); http://dx.doi.org/10.1063/1.3179149 (3 pages)

Online Publication Date: 30 July 2009

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The traceability of polyethylcyanoacrylate nanoparticles transported through human skin is studied in this paper. Photoluminescence is used to find the precise diffusion path of polyethylcyanoacrylate nanoparticles through the skin stratum corneum (SC). Reproducible data were obtained, and the nanoparticles’ distribution in each layer of the SC is presented. We contribute to the basic knowledge of these phenomena as a stationary stochastic process using a one-dimensional linear chain model with the left end open and the right end closed. Possible applications are in the field of pharmaceutical technology, especially concerning drug transport through the skin by nanoparticle carriers.
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87.85.Rs Nanotechnologies-applications
78.55.Kz Solid organic materials
78.67.Bf Nanocrystals, nanoparticles, and nanoclusters

Multiphoton autofluorescence spectral analysis for fungus imaging and identification

Sung-Jan Lin (林頌然), Hsin-Yuan Tan (譚欣媛), Chien-Jui Kuo (郭千睿), Ruei-Jr Wu (吳瑞智), Shiou-Han Wang (王修含), Wei-Liang Chen (陳維良), Shiou-Hwa Jee (紀秀華), and Chen-Yuan Dong (董成淵)

Appl. Phys. Lett. 95, 043703 (2009); http://dx.doi.org/10.1063/1.3189084 (3 pages) | Cited 1 time

Online Publication Date: 30 July 2009

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We performed multiphoton imaging on fungi of medical significance. Fungal hyphae and spores of Aspergillus flavus, Micosporum gypseum, Micosoprum canis, Trichophyton rubrum, and Trichophyton tonsurans were found to be strongly autofluorescent but generate less prominent second harmonic signal. The cell wall and septum of fungal hyphae can be easily identified by autofluorescence imaging. We found that fungi of various species have distinct autofluorescence characteristics. Our result shows that the combination of multiphoton imaging and spectral analysis can be used to visualize and identify fungal species. This approach may be developed into an effective diagnostic tool for fungal identification.
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87.64.kv Fluorescence
87.18.-h Biological complexity
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