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17 Aug 2009

Volume 95, Issue 7, Articles (07xxxx)

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Appl. Phys. Lett. 95, 073703 (2009); http://dx.doi.org/10.1063/1.3152768 (3 pages)

Mohammud R. Noor, Swati Goyal, Shawn M. Christensen, and Samir M. Iqbal
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Single beam acoustic trapping

Jungwoo Lee, Shia-Yen Teh, Abraham Lee, Hyung Ham Kim, Changyang Lee, and K. Kirk Shung

Appl. Phys. Lett. 95, 073701 (2009); http://dx.doi.org/10.1063/1.3206910 (3 pages) | Cited 12 times

Online Publication Date: 17 August 2009

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A single beam acoustic device, with its relatively simple scheme and low intensity, can trap a single lipid droplet in a manner similar to optical tweezers. Forces in the order of hundreds of nanonewtons direct the droplet toward the beam focus, within the range of hundreds of micrometers. This trapping method, therefore, can be a useful tool for particle manipulation in areas where larger particles or forces are involved.
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43.38.-p Transduction; acoustical devices for the generation and reproduction of sound
42.50.Wk Mechanical effects of light on material media, microstructures and particles

Particle-chain formation in a dc dielectrophoretic trap; a reaction-diffusion approach

O. E. Nicotra, A. La Magna, and S. Coffa

Appl. Phys. Lett. 95, 073702 (2009); http://dx.doi.org/10.1063/1.3177332 (3 pages) | Cited 1 time

Online Publication Date: 17 August 2009

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Dielectrophoresis has proven to be an effective method for the separation of bioparticles such as cells. Nevertheless, the electric polarization induced by nonuniform electric fields leads to a dipole-dipole interaction between particles and therefore the formation of chains is likely to occur. In this paper, we will present an approach based on a drift-diffusion dynamics to quantitatively study formation and kinetics of particle-chains via the introduction of the particle stitching as chemical-like reactions. This approach will allow us to dynamically describe, in the framework of a numerical simulation, particle clustering, thus providing a suitable tool for reproducing data from dielectrophoretic experimental setup.
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82.45.-h Electrochemistry and electrophoresis
77.22.Ej Polarization and depolarization
66.30.Dn Theory of diffusion and ionic conduction in solids

Electrical detection of single-base DNA mutation using functionalized nanoparticles

Mohammud R. Noor, Swati Goyal, Shawn M. Christensen, and Samir M. Iqbal

Appl. Phys. Lett. 95, 073703 (2009); http://dx.doi.org/10.1063/1.3152768 (3 pages) | Cited 4 times

Online Publication Date: 17 August 2009

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We report an electrical scheme to detect specific DNA. Engineered hairpin probe DNA are immobilized on a silicon chip between gold nanoelectrodes. Hybridization of target DNA to the hairpin melts the stem nucleotides. Gold nanoparticle-conjugated universal reporter sequence detects the open hairpins by annealing to the exposed stem nucleotides. The gold nanoparticles increase charge conduction between the electrodes. Specifically, we report on a hairpin probe designed to detect a medically relevant mutant form of the K-ras oncogene. Direct current measurements show three orders of magnitude increase in conductivity for as low as 2 fmol of target molecules.
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87.85.Rs Nanotechnologies-applications
87.15.Pc Electronic and electrical properties
87.14.gk DNA

Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes

I. Putu Mahendra Wijaya, Sonu Gandhi, Tey Ju Nie, Nishima Wangoo, Isabel Rodriguez, G. Shekhawat, C. Raman Suri, and Subodh G. Mhaisalkar

Appl. Phys. Lett. 95, 073704 (2009); http://dx.doi.org/10.1063/1.3211328 (3 pages) | Cited 11 times

Online Publication Date: 21 August 2009

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Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.
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87.15.hp Conformational changes
87.15.Pc Electronic and electrical properties
87.15.R- Reactions and kinetics
36.20.-r Macromolecules and polymer molecules
87.14.E- Proteins
87.15.B- Structure of biomolecules

Highly parallel measurements of interaction kinetic constants with a microfabricated optomechanical device

Steven R. Bates and Stephen R. Quake

Appl. Phys. Lett. 95, 073705 (2009); http://dx.doi.org/10.1063/1.3211382 (3 pages) | Cited 9 times

Online Publication Date: 21 August 2009

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We used mechanical trapping of molecular interactions to demonstrate a highly parallel approach to measure the kinetics of biomolecular interactions. This approach consumes 25 fmol of material per measurement and permits 320 measurements in a single experiment. We measured association and dissociation curves for the interactions of 6-His and T7 epitope tags with their antibodies, from which we determined the off rates, on rates, and dissociation constants.
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87.15.rs Dissociation
87.14.E- Proteins
87.80.Ek Mechanical and micromechanical techniques
82.20.Pm Rate constants, reaction cross sections, and activation energies
47.85.Np Fluidics
07.10.Cm Micromechanical devices and systems
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