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Applied Physics Letters / Volume 96 / Issue 10 / PLASMAS AND ELECTRICAL DISCHARGES

Appl. Phys. Lett. 96, 101501 (2010); http://dx.doi.org/10.1063/1.3352316 (3 pages)

Plasma effects on subcellular structures

Bomi Gweon1, Daeyeon Kim2, Dan Bee Kim1, Heesoo Jung1, Wonho Choe1, and Jennifer H. Shin2,3

1Department of Physics, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea
2Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea
3Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea

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(Received 16 October 2009; accepted 11 January 2010; published online 8 March 2010)

Atmospheric pressure helium plasma treated human hepatocytes exhibit distinctive zones of necrotic and live cells separated by a void. We propose that plasma induced necrosis is attributed to plasma species such as oxygen radicals, charged particles, metastables and/or severe disruption of charged cytoskeletal proteins. Interestingly, uncharged cytoskeletal intermediate filaments are only minimally disturbed by plasma, elucidating the possibility of plasma induced electrostatic effects selectively destroying charged proteins. These bona fide plasma effects, which inflict alterations in specific subcellular structures leading to necrosis and cellular detachment, were not observed by application of helium flow or electric field alone.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

bioelectric phenomena, biological effects of fields, biological effects of ionising particles, cellular biophysics, helium, liver, molecular biophysics, plasma interactions, proteins

PACS

  • 87.53.-j

    Effects of ionizing radiation on biological systems

  • 87.50.cf

    Biophysical mechanisms of interaction

  • 87.17.-d

    Cell processes

  • 87.15.Pc

    Electronic and electrical properties

  • 52.40.-w

    Plasma interactions (nonlaser)

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3352316

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    M. Laroussi, J. P. Richardson, and F. C. Dobbs, Appl. Phys. Lett. 81, 772 (2002)APPLAB000081000004000772000001.

    A. Shashurin, M. Keidar, S. Bronnikov, R. A. Jurjus, and M. A. Stepp, Appl. Phys. Lett. 93, 181501 (2008)APPLAB000093000018181501000001.

    D. B. Kim, J. K. Rhee, S. Y. Moon, and W. Choe, Appl. Phys. Lett. 89, 061502 (2006)APPLAB000089000006061502000001.

    D. F. Opaits, M. N. Shneider, R. B. Miles, A. V. Likhanskii, and S. O. Macheret, Phys. Plasmas 15, 073505 (2008)PHPAEN000015000007073505000001.


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