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Applied Physics Letters / Volume 96 / Issue 18 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 96, 183702 (2010); http://dx.doi.org/10.1063/1.3427354 (3 pages)

Programmed packaging of multicomponent envelope-type nanoparticle system for gene delivery

Daniela Pozzi1, Carlotta Marianecci2, Maria Carafa2, Cristina Marchini3, Maura Montani3, Augusto Amici3, and Giulio Caracciolo1

1Department of Chemistry, Faculty of Medicine, ‘Sapienza’ University of Rome, P.le A. Moro 5, 00185 Rome, Italy
2Department of Drug Chemistry and Technologies, Faculty of Pharmacy, ‘Sapienza’ University of Rome, P.le A. Moro 5, 00185 Rome, Italy
3Department of Molecular Cellular and Animal Biology, University of Camerino, Via Gentile III da Varano, 62032 Camerino (MC), Italy

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(Received 26 March 2010; accepted 15 April 2010; published online 5 May 2010)

A programmed packaging strategy to develop a multicomponent envelope-type nanoparticle system (MENS) is presented. To this end, we took specific advantage of using in-house tailored liposomes that have been recently shown to exhibit intrinsic endosomal rupture properties that allow plasmid DNA to escape from endosomes and to enter the nucleus with extremely high efficiency. Transfection efficiency experiments on NIH 3T3 mouse fibroblasts indicate that MENS is a promising transfection candidate.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomechanics, biomedical materials, cellular biophysics, DNA, fracture, genetic engineering, genetics, nanobiotechnology, nanoparticles

PACS

  • 87.85.md

    Genetic engineering

  • 87.85.jc

    Electrical, thermal, and mechanical properties of biological matter

  • 87.85.Rs

    Nanotechnologies-applications

  • 87.16.dm

    Mechanical properties and rheology

  • 87.17.Rt

    Cell adhesion and cell mechanics

  • 87.14.gk

    DNA

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3427354

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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