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17 May 2010

Volume 96, Issue 20, Articles (20xxxx)

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Appl. Phys. Lett. 96, 203102 (2010); http://dx.doi.org/10.1063/1.3429125 (3 pages)

Qimin Quan, Parag B. Deotare, and Marko Loncar
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A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy

Jae Young Kim, Sung-O Kim, Yanzhang Wei, and Jinhua Li

Appl. Phys. Lett. 96, 203701 (2010); http://dx.doi.org/10.1063/1.3431392 (3 pages) | Cited 20 times

Online Publication Date: 17 May 2010

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This paper describes a flexible microplasma jet device using a Tygon® S-54-HL tube as a biocompatible tube and its potential in developing cancer therapies. The optical and physical properties of the plasma jets and preliminary apoptosis data of cultured murine tumor cells and nontumor fibroblast cells treated with these plasma jets are presented. Microplasma jets were observed to induce apoptosis in cultured murine cells in a dose-dependent manner. The murine melanoma tumor cells were more sensitive to plasma treatment than fibroblast cells. These features allow the direct and precise application of this microplasma jet device to tumor cells.
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87.85.J- Biomaterials
87.17.-d Cell processes
52.77.-j Plasma applications

Modified ion sensitive field effect transistor sensors having an extended gate on a thick dielectric

Chang-Geun Ahn, Ansoon Kim, Chan Woo Park, Chil Seong Ah, Jong-Heon Yang, Tae-Youb Kim, Moongyu Jang, and Gun Yong Sung

Appl. Phys. Lett. 96, 203702 (2010); http://dx.doi.org/10.1063/1.3431296 (3 pages)

Online Publication Date: 19 May 2010

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Modified ion sensitive field effect transistors having an extended gate (EG) on a thick dielectric have been developed to obtain extremely high sensitivity. The capacitance of the EG is controlled to be very small via the thickness of the dielectric layer so that it may be ignored when compared with the gate capacitance of the transistor. As a result, the gate voltage can be fully dependent on the surface charge of the EG. When microalbumin protein of concentration 1 μg/ml on a monoclonal antibody of a microalbumin surface of the EG is injected, an extremely high sensitivity of 1800% is observed.
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85.30.Tv Field effect devices
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