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24 May 2010

Volume 96, Issue 21, Articles (21xxxx)

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Appl. Phys. Lett. 96, 213701 (2010); http://dx.doi.org/10.1063/1.3431628 (3 pages)

Satish Rao, Saurabh Raj, Stefan Balint, Carlota Bardina Fons, Susana Campoy, Montserrat Llagostera, and Dmitri Petrov
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Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Satish Rao, Saurabh Raj, Stefan Balint, Carlota Bardina Fons, Susana Campoy, Montserrat Llagostera, and Dmitri Petrov

Appl. Phys. Lett. 96, 213701 (2010); http://dx.doi.org/10.1063/1.3431628 (3 pages) | Cited 15 times

Online Publication Date: 24 May 2010

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Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule.
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87.15.M- Spectra of biomolecules
78.30.-j Infrared and Raman spectra
87.14.gk DNA

Optical sensing of square lattice photonic crystal point-shifted nanocavity for protein adsorption detection

Tsan-Wen Lu, Pin-Tso Lin, Kuan-Un Sio, and Po-Tsung Lee

Appl. Phys. Lett. 96, 213702 (2010); http://dx.doi.org/10.1063/1.3436550 (3 pages) | Cited 5 times

Online Publication Date: 24 May 2010

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We propose a point-shifted D0 nanocavity formed by locally modulating four central air holes in square lattice photonic crystal for optical sensing application. Three defect modes in this nanocavity, including monopole, whispering-gallery, and dipole modes, are identified in experiments. We also apply a chemical treatment on InGaAsP surface to form a 1-octadecanethiol linking monolayer, which enables the following protein adsorption. In experiments, the wavelength shifts of lasing modes in the D0 nanocavity due to the protein adsorption are observed and agree with the simulation results. This can be a practical tool for label-free molecule detection in biomedical researches.
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07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
42.70.Qs Photonic bandgap materials
87.15.N- Properties of solutions of macromolecules
87.14.E- Proteins

Biocompatibility of single crystalline Fe70Pd30 ferromagnetic shape memory films

Y. Ma, M. Zink, and S. G. Mayr

Appl. Phys. Lett. 96, 213703 (2010); http://dx.doi.org/10.1063/1.3435260 (3 pages) | Cited 9 times

Online Publication Date: 25 May 2010

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Controllable by an external magnetic field, ferromagnetic shape memory materials reveal a high potential for actuators in biomedical applications. Simulated body fluid (SBF) and cell tests were performed to assess the biocompatibility of Fe70Pd30 ferromagnetic shape memory thin films as grown on MgO substrates. Calcium-phosphate aggregates were detected on the film surface after soaking in SBF. Biocompatibility tests with NIH 3T3 fibroblasts revealed adhesion and proliferation on the film surface but morphological modifications with a reduced cell size became evident as well as changes in cell viability for continuous and noncontinuous FePd films. The results are compared to FePd on SiO2.
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87.85.J- Biomaterials
64.70.K- Solid-solid transitions
62.20.fg Shape-memory effect; yield stress; superelasticity
75.50.Bb Fe and its alloys
87.17.Aa Modeling, computer simulation of cell processes

Quantitatively linking collagen alteration and epithelial tumor progression by second harmonic generation microscopy

Shuangmu Zhuo, Jianxin Chen, Guizhu Wu, Shusen Xie, Liqin Zheng, Xingshan Jiang, and Xiaoqin Zhu

Appl. Phys. Lett. 96, 213704 (2010); http://dx.doi.org/10.1063/1.3441337 (3 pages) | Cited 13 times

Online Publication Date: 26 May 2010

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Collagen alteration is critical for epithelial tumor initiation and progression. Quantitatively linking collagen alteration and epithelial tumor progression is essential for developing an optical endoscopy to evaluate epithelial tumor progression. In this work, we established a quantitative link between collagen alteration and epithelial tumor progression using second harmonic generation (SHG) microscopy. It was found that SHG microscopy can provide quantitative features to effectively evaluate epithelial tumor progression, and to locate tumor and determine the margin of tumor regions. These results suggest that SHG microscopy has the potential in offering a noninvasive in vivo imaging tool to quantify epithelial tumor progression.
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87.64.M- Optical microscopy
87.63.L- Visual imaging

Single cell contractility studies based on compact moiré system over periodic gratings

Xiaoyu Zheng, Howard Surks, and Xin Zhang

Appl. Phys. Lett. 96, 213705 (2010); http://dx.doi.org/10.1063/1.3432448 (3 pages)

Online Publication Date: 26 May 2010

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Abnormal vascular cell contractile performance is a hallmark of cardiovascular diseases. Conventional cell force measurement technique requires individually tracking the sensing units and complex computation efforts for further studying cell contractility. We developed instead a robust and simple compact optical moiré system that measures phase changes encoded in carrier moiré patterns generated from two layers of gratings. Cell mechanics study including cell contractile forces and stress and strain distributions during normal and abnormal cell contractions can thus be conveniently analyzed. The distinct signals from moiré patterns in longitudinal and transverse directions revealed abnormal cell mechanical contractility linked to cardiovascular disease.
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87.17.Rt Cell adhesion and cell mechanics
87.64.K- Spectroscopy
07.60.Ly Interferometers
87.19.X- Diseases

Improved stability of free-standing lipid bilayers based on nanoporous alumina films

Ayumi Hirano-Iwata, Tasuku Taira, Azusa Oshima, Yasuo Kimura, and Michio Niwano

Appl. Phys. Lett. 96, 213706 (2010); http://dx.doi.org/10.1063/1.3441298 (3 pages) | Cited 3 times

Online Publication Date: 28 May 2010

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In this study, we propose a method for improving the stability of free-standing bilayer lipid membranes (BLMs) by preparing BLMs across nanoporous alumina films. The use of porous alumina reduced individual membrane size to improve the BLM stability. The BLMs were stable under an applied voltage of ±1 V. The lifetime of the BLMs was 16–30 h with and without incorporated gramicidin channels. Electric properties of the BLMs as a platform for channel-current recordings are also discussed. Since the total area of the BLMs is still large to facilitate protein incorporation, our approach is useful for designing highly sensitive biosensors based on channel proteins.
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87.16.D- Membranes, bilayers, and vesicles
87.14.Cc Lipids
87.85.Rs Nanotechnologies-applications
61.43.Gt Powders, porous materials
61.46.-w Structure of nanoscale materials
87.15.-v Biomolecules: structure and physical properties
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