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Applied Physics Letters / Volume 96 / Issue 22 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 96, 223701 (2010); http://dx.doi.org/10.1063/1.3447365 (3 pages)

Role of nuclear tubule on the apoptosis of HeLa cells induced by femtosecond laser

Hao He1, Kam Tai Chan1, and Siu Kai Kong2

1Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong
2Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

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(Received 29 April 2010; accepted 13 May 2010; published online 2 June 2010)

It was found that nuclear tubules (NTs) would develop inside the nuclei of HeLa cells when they were irradiated by a femtosecond laser at the wavelength of 1554 nm for 40 s or longer. These NTs provided a pathway for the excess calcium generated by the laser to diffuse from the cytoplasm to the nucleus. Concurrently, the NTs served to spread mitochondria deep inside the nucleus so that they could initiate DNA fragmentations in regions covered by the NTs in the apoptotic cell. The role of NT as the precursor and passage to apoptosis is firmly established.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

biological effects of laser radiation, cellular effects of radiation, DNA, high-speed optical techniques, laser applications in medicine

PACS

  • 87.16.-b

    Subcellular structure and processes

  • 87.50.W-

    Optical/infrared radiation effects

  • 87.14.gk

    DNA

  • 42.65.Re

    Ultrafast processes; optical pulse generation and pulse compression

  • 42.62.Be

    Biological and medical applications

  • 87.50.wp

    Therapeutic applications

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3447365

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    H. He, K. T. Chan, S. K. Kong, and R. K. Y. Lee, Appl. Phys. Lett. 95, 233702 (2009)APPLAB000095000023233702000001.


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