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Applied Physics Letters / Volume 96 / Issue 22 / INTERDISCIPLINARY AND GENERAL PHYSICS

Appl. Phys. Lett. 96, 224101 (2010); http://dx.doi.org/10.1063/1.3431664 (3 pages)

Hydrodynamic trap for single particles and cells

Melikhan Tanyeri1, Eric M. Johnson-Chavarria2, and Charles M. Schroeder1,2

1Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
2Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

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(Received 31 March 2010; accepted 24 April 2010; published online 2 June 2010)

Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1–10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm–15 μm) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 μm of the trap center, corresponding to a trap stiffness of ∼ 10−5–10−4 pN/nm.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

hydrodynamics, microfluidics, multiphase flow, stagnation flow, viscosity

PACS

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

  • 66.20.-d

    Viscosity of liquids; diffusive momentum transport

  • 47.61.Jd

    Multiphase flows

  • 47.55.Kf

    Particle-laden flows

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3431664

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    A. E. Cohen, Phys. Rev. Lett. 94, 118102 (2005).

    H. Lee, A. M. Purdon, and R. M. Westervelt, Appl. Phys. Lett. 85, 1063 (2004)APPLAB000085000006001063000001.


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