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14 Jun 2010

Volume 96, Issue 24, Articles (24xxxx)

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Appl. Phys. Lett. 96, 241101 (2010); http://dx.doi.org/10.1063/1.3449576 (3 pages)

Rui Chen, H. D. Sun, T. Wang, K. N. Hui, and H. W. Choi
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Effects of atmospheric nonthermal plasma on invasion of colorectal cancer cells

Chul-Ho Kim, Seyeoul Kwon, Jae Hoon Bahn, Keunho Lee, Seung Ik Jun, Philip D. Rack, and Seung Joon Baek

Appl. Phys. Lett. 96, 243701 (2010); http://dx.doi.org/10.1063/1.3449575 (3 pages) | Cited 5 times

Online Publication Date: 14 June 2010

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The effect that the gas content and plasma power of atmospheric, nonthermal plasma has on the invasion activity in colorectal cancer cells has been studied. Helium and helium plus oxygen plasmas were induced through a nozzle and operated with an ac power of less than 10 kV which exhibited a length of 2.5 cm and a diameter of 3–4 mm in ambient air. Treatment of cancer cells with the plasma jet resulted in a decrease in cell migration/invasion with higher plasma intensity and the addition of oxygen to the He flow gas.
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87.17.Ee Growth and division
87.19.xj Cancer
87.85.-d Biomedical engineering

Thin films of polymer blends for controlled drug delivery deposited by matrix-assisted pulsed laser evaporation

Irina Alexandra Paun, Valentin Ion, Antoniu Moldovan, and Maria Dinescu

Appl. Phys. Lett. 96, 243702 (2010); http://dx.doi.org/10.1063/1.3453756 (3 pages) | Cited 5 times

Online Publication Date: 15 June 2010

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We demonstrate the use of matrix-assisted pulsed laser evaporation technique for incorporating drugs (indomethacin) within thin films of polymer blends, to be used as biodegradable implants that deliver drugs in a controlled manner. For irradiation at fluences up to 1 J/cm2, the films show excellent surface morphology and the chemical structure of all constituent polymers within the blend is well preserved. The optical characteristics of the films are assessed by spectroscopic ellipsometry. The presence of the drug within the polymeric films is confirmed by its specific absorption at 319 nm.
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87.85.J- Biomaterials
68.35.bm Polymers, organics
68.55.am Polymers and organics
78.66.Qn Polymers; organic compounds
81.15.Fg Pulsed laser ablation deposition

Positioning and stretching of actin filaments by electric fields

Christoph Wigge, Horst Hinssen, Günter Reiss, and Simone Herth

Appl. Phys. Lett. 96, 243703 (2010); http://dx.doi.org/10.1063/1.3455338 (3 pages) | Cited 1 time

Online Publication Date: 18 June 2010

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The alignment of biological filaments on surfaces offers a high potential for controllable geometries in lab-on-a-chip-structures and micrototal analysis systems. Actin is a polar filamentous protein with a diameter of 7–8 nm that can be manipulated with strong electric fields. It is demonstrated that with the use of microelectrodes or nanoelectrodes and electric fields of 20 kV/m single actin filaments can be manipulated, stretched, and positioned between gold electrodes.
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87.85.Rs Nanotechnologies-applications
87.14.E- Proteins
87.50.C- Static and low-frequency electric and magnetic fields effects
87.15.-v Biomolecules: structure and physical properties
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