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Applied Physics Letters / Volume 96 / Issue 26 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 96, 263701 (2010); http://dx.doi.org/10.1063/1.3457473 (3 pages)

Biosensor regeneration via substrate electric potential: A physical mechanism

Rui-Bin Jiang and U. Lei

Institute of Applied Mechanics, National Taiwan University, Taipei 10617, Taiwan

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(Received 28 April 2010; accepted 3 June 2010; published online 28 June 2010)

Literatures showed that the immune type biosensors can be regenerated by applying a voltage (ΔΦ) across the combined macromolecules but the underlying physics was not clarified. By incorporating an electric double layer force and a van der Waals force into a weight-ensemble Brownian dynamics simulation, we found that the dissociation rate constant for biotin-streptavidin increases exponentially with ΔΦ, and reaches 418-fold when ΔΦ equals 1 V. Macroscopic diffusion simulations using such enhanced dissociation rate constants agree with the previous experiments, and explain quantitatively the finding that the regeneration using square-wave voltage is superior to that using saw-tooth voltage.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

biochemistry, bioelectric phenomena, biomolecular effects of radiation, biosensors, dissociation, electrochemical sensors, electrochemistry, van der Waals forces

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3457473

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    D. L. Ermak and J. A. McCammon, J. Chem. Phys. 69, 1352 (1978)JCPSA6000069000004001352000001.

    J. Spinke, M. Liley, F. J. Schmitt, H. J. Guder, L. Angermaier, and W. Knoll, J. Chem. Phys. 99, 7012 (1993)JCPSA6000099000009007012000001.


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