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28 Jun 2010

Volume 96, Issue 26, Articles (26xxxx)

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Appl. Phys. Lett. 96, 261101 (2010); http://dx.doi.org/10.1063/1.3456618 (3 pages)

I. V. Konoplev, L. Fisher, A. W. Cross, A. D. R. Phelps, K. Ronald, and C. W. Robertson
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Biosensor regeneration via substrate electric potential: A physical mechanism

Rui-Bin Jiang and U. Lei

Appl. Phys. Lett. 96, 263701 (2010); http://dx.doi.org/10.1063/1.3457473 (3 pages)

Online Publication Date: 28 June 2010

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Literatures showed that the immune type biosensors can be regenerated by applying a voltage (ΔΦ) across the combined macromolecules but the underlying physics was not clarified. By incorporating an electric double layer force and a van der Waals force into a weight-ensemble Brownian dynamics simulation, we found that the dissociation rate constant for biotin-streptavidin increases exponentially with ΔΦ, and reaches 418-fold when ΔΦ equals 1 V. Macroscopic diffusion simulations using such enhanced dissociation rate constants agree with the previous experiments, and explain quantitatively the finding that the regeneration using square-wave voltage is superior to that using saw-tooth voltage.
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87.80.Kc Electrochemical techniques
87.15.Pc Electronic and electrical properties
87.15.rs Dissociation
82.47.Rs Electrochemical sensors
82.45.Tv Bioelectrochemistry

Electron transfer mechanism of cytochrome c at graphene electrode

Subbiah Alwarappan, Rakesh K. Joshi, Manoj K. Ram, and Ashok Kumar

Appl. Phys. Lett. 96, 263702 (2010); http://dx.doi.org/10.1063/1.3458698 (3 pages) | Cited 18 times

Online Publication Date: 29 June 2010

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We report the direct electron transfer of cytochrome c (Cyt c) observed at graphene electrodes. Graphene nanosheets were chemically synthesized and immobilized on to a glassy carbon electrode. Cyclic voltammetry of Cyt c in phosphate buffered saline was performed at these electrodes. Results indicated a pair of reversible redox waves with a peak-to-peak separation value of 0.07 V in a diffusion controlled electrochemical process. Furthermore, the voltammetric response of these electrodes in Cyt c were found to be stable over time with negligible electrode fouling toward Cyt c.
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87.15.R- Reactions and kinetics
82.80.Fk Electrochemical methods
87.80.Kc Electrochemical techniques
82.45.Fk Electrodes
87.14.E- Proteins
82.45.Tv Bioelectrochemistry
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