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11 Jan 2010

Volume 96, Issue 2, Articles (02xxxx)

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Appl. Phys. Lett. 96, 021101 (2010); http://dx.doi.org/10.1063/1.3290633 (3 pages)

Ahmet Ali Yanik, Min Huang, Alp Artar, Tsung-Yao Chang, and Hatice Altug
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Observation of negative differential resistance in DNA molecular junctions

Ning Kang, Artur Erbe, and Elke Scheer

Appl. Phys. Lett. 96, 023701 (2010); http://dx.doi.org/10.1063/1.3291113 (3 pages) | Cited 6 times

Online Publication Date: 12 January 2010

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The mechanically controllable break junction technique is used to study charge transport through suspended DNA molecules. The current-voltage (I-V) characteristics in an aqueous solution display series of negative differential resistance (NDR) and hysteresis behavior. Under high-vacuum conditions, the peak positions of NDR shift to lower voltage, and the amplitude is reduced dramatically. The observed NDR behavior is consistent with the polarization mechanism in DNA molecular junctions, which demonstrates a change in the coupling of the molecular level to a polaron mode under different environment.
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87.15.Pc Electronic and electrical properties
33.20.Tp Vibrational analysis
34.70.+e Charge transfer
87.14.gk DNA

Computed tomographic x-ray velocimetry

S. Dubsky, R. A. Jamison, S. C. Irvine, K. K. W. Siu, K. Hourigan, and A. Fouras

Appl. Phys. Lett. 96, 023702 (2010); http://dx.doi.org/10.1063/1.3285173 (3 pages) | Cited 11 times

Online Publication Date: 12 January 2010

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An x-ray velocimetry technique is described which provides three components of velocity measurement in three dimensional space. Current x-ray velocimetry techniques, which use particle images taken at a single projection angle, are limited to two components of velocity measurement, and are unable to measure in three dimensions without a priori knowledge of the flow field. The proposed method uses multiple projection angles to overcome these limitations. The technique uses a least-squares iterative scheme to tomographically reconstruct the three-dimensional velocity field directly from two-dimensional image pair cross-correlations, without the need to reconstruct three-dimensional particle images. Synchrotron experiments demonstrate the effectiveness of the technique for blood flow measurement in opaque vessels, with applications for the diagnosis and treatment of cardiovascular disease.
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87.57.Q- Computed tomography
06.30.Gv Velocity, acceleration, and rotation
87.85.gf Fluid mechanics and rheology
87.19.U- Hemodynamics
87.19.Hh Cardiac dynamics
87.57.nf Reconstruction

Effect of osteogenesis imperfecta mutations in tropocollagen molecule on strength of biomimetic tropocollagen-hydroxyapatite nanocomposites

Devendra K. Dubey and Vikas Tomar

Appl. Phys. Lett. 96, 023703 (2010); http://dx.doi.org/10.1063/1.3279158 (3 pages) | Cited 3 times

Online Publication Date: 12 January 2010

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Osteogenesis Imperfecta (OI) is a genetic disorder that affects cellular synthesis of Type-I collagen fibrils and causes extreme bone fragility. This study reports the effects of OI mutations in Tropocollagen (TC) molecules on strength of model Tropocollagen-Hydroxyapatite biomaterials with two different mineral [hydroxyapatite (HAP)] distributions using three dimensional atomistic simulations. Results show that the effect of TC mutations on the strength of TC-HAP biomaterials is insignificant. Instead, change in mineral distribution showed significant impact on the overall strength of TC-HAP biomaterials. Study suggests that TC mutations manifest themselves by changing the mineral distribution during hydroxyapatite growth and nucleation period.
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87.85.J- Biomaterials
87.17.Ee Growth and division
87.14.E- Proteins
87.19.xk Genetic diseases
87.15.-v Biomolecules: structure and physical properties
87.85.Rs Nanotechnologies-applications
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