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18 Jan 2010

Volume 96, Issue 3, Articles (03xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 96, 033101 (2010); http://dx.doi.org/10.1063/1.3291849 (3 pages)

Ferruccio Pisanello, Luigi Martiradonna, Godefroy Leménager, Piernicola Spinicelli, Angela Fiore, Liberato Manna, Jean-Pierre Hermier, Roberto Cingolani, Elisabeth Giacobino, Massimo De Vittorio, and Alberto Bramati
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A dielectric affinity microbiosensor

Xian Huang, Siqi Li, Jerome S. Schultz, Qian Wang, and Qiao Lin

Appl. Phys. Lett. 96, 033701 (2010); http://dx.doi.org/10.1063/1.3291669 (3 pages) | Cited 4 times

Online Publication Date: 19 January 2010

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We present an affinity biosensing approach that exploits changes in dielectric properties of a polymer due to its specific, reversible binding with an analyte. The approach is demonstrated using a microsensor comprising a pair of thin-film capacitive electrodes sandwiching a solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid), a synthetic polymer with specific affinity to glucose. Binding with glucose induces changes in the permittivity of the polymer, which can be measured capacitively for specific glucose detection, as confirmed by experimental results at physiologically relevant concentrations. The dielectric affinity biosensing approach holds the potential for practical applications such as long-term continuous glucose monitoring.
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87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
87.85.J- Biomaterials
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
07.10.Cm Micromechanical devices and systems
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

Measurement of molecular binding using the Brownian motion of magnetic nanoparticle probes

Adam M. Rauwerdink and John B. Weaver

Appl. Phys. Lett. 96, 033702 (2010); http://dx.doi.org/10.1063/1.3291063 (3 pages) | Cited 7 times

Online Publication Date: 20 January 2010

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Molecular binding is important in many venues including antibody binding for diagnostic and therapeutic agents and pharmaceutical function. We demonstrate that a method of measuring nanoparticle Brownian motion, termed magnetic spectroscopy of nanoparticle Brownian motion (MSB), can be used to monitor molecular binding and the bound fraction. It is plausible that MSB can be used to measure binding in vivo because the same signal has been used to image nanoparticles in nanogram quantities in vivo.
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87.15.hg Dynamics of intermolecular interactions
87.14.E- Proteins

An underlap field-effect transistor for electrical detection of influenza

Kwang-Won Lee, Sung-Jin Choi, Jae-Hyuk Ahn, Dong-Il Moon, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi

Appl. Phys. Lett. 96, 033703 (2010); http://dx.doi.org/10.1063/1.3291617 (3 pages) | Cited 3 times

Online Publication Date: 21 January 2010

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An underlap channel-embedded field-effect transistor (FET) is proposed for label-free biomolecule detection. Specifically, silica binding protein fused with avian influenza (AI) surface antigen and avian influenza antibody (anti-AI) were designed as a receptor molecule and a target material, respectively. The drain current was significantly decreased after the binding of negatively charged anti-AI on the underlap channel. A set of control experiments supports that only the biomolecules on the underlap channel effectively modulate the drain current. With the merits of a simple fabrication process, complementary metal-oxide-semiconductor compatibility, and enhanced sensitivity, the underlap FET could be a promising candidate for a chip-based biosensor.
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87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
87.19.xd Viral diseases
85.30.Tv Field effect devices

Effects of particle size and ligand density on the kinetics of receptor-mediated endocytosis of nanoparticles

Hongyan Yuan and Sulin Zhang

Appl. Phys. Lett. 96, 033704 (2010); http://dx.doi.org/10.1063/1.3293303 (3 pages) | Cited 11 times

Online Publication Date: 22 January 2010

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We elucidate, from thermodynamic arguments, the governing factors of receptor-mediated endocytosis of nanoparticles (NPs). We show that the endocytic energetics specifies a minimal particle size and a minimal ligand density below which endocytosis is not possible. Due to the entropic penalty involved in ligand-receptor binding, endocytosis may occur with a large fraction of ligands unbound with receptors. Our analyses suggest that the endocytic time depends interrelatedly on the particle size and ligand density. There exists an optimal condition at which the endocytic time minimizes. These findings may provide valuable guidance to the rational designs of NP-based biomarkers and anticancer bioagents.
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87.85.Rs Nanotechnologies-applications
87.85.J- Biomaterials
82.39.-k Chemical kinetics in biological systems
87.15.R- Reactions and kinetics
87.17.-d Cell processes
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