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1 Feb 2010

Volume 96, Issue 5, Articles (05xxxx)

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Appl. Phys. Lett. 96, 053107 (2010); http://dx.doi.org/10.1063/1.3280078 (3 pages)

Desalegne Teweldebrhan, Vivek Goyal, Muhammad Rahman, and Alexander A. Balandin
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Highly selective separation of DNA fragments using optically directed transport

Avital Braiman, Fedor Rudakov, and Thomas Thundat

Appl. Phys. Lett. 96, 053701 (2010); http://dx.doi.org/10.1063/1.3298743 (3 pages) | Cited 3 times

Online Publication Date: 2 February 2010

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We present a design that allows selective separation of biomolecules of a particular size without performing complete separation of the sample by size. By focusing a laser beam onto a photoelectrode in contact with an electrolyte medium, a highly localized and optically controlled photoelectrophoretic trap is created. Moving the light beam along the photoelectrode consequently moves the trap. We demonstrate that by manipulating the speed of the photoelectrophoretic trap biomolecules of a particular size can be selectively separated from the mixture. We achieve a qualitative agreement between our experimental results and numerical simulations.
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87.14.gk DNA
87.15.-v Biomolecules: structure and physical properties
87.50.wf Biophysical mechanisms of interaction

Charge pumping technique to analyze the effect of intrinsically retained charges and extrinsically trapped charges in biomolecules by use of a nanogap embedded biotransistor

Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi

Appl. Phys. Lett. 96, 053702 (2010); http://dx.doi.org/10.1063/1.3300838 (3 pages) | Cited 3 times

Online Publication Date: 3 February 2010

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Charge pumping technique is investigated for label-free electrical biosensing using a nanogap-embedded biotransistor. Biomolecules immobilized in a nanogap provide additional trap states and charges in the gate dielectric. These two effects give rise to a change of the charge pumping current, which are analyzed by the aid of numerical simulations. To utilize the trap density of gate dielectric as a sensing parameter, proper amplitude of pulse should be applied for charge pumping to exclude the effect of intrinsically retained charges in biomolecules, thereby this proposed technique is available for detection of biomolecules regardless of retained charges.
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87.85.-d Biomedical engineering
87.80.-y Biophysical techniques (research methods)
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A contour-mode film bulk acoustic resonator of high quality factor in a liquid environment for biosensing applications

Wencheng Xu, Seokheun Choi, and Junseok Chae

Appl. Phys. Lett. 96, 053703 (2010); http://dx.doi.org/10.1063/1.3309586 (3 pages) | Cited 18 times

Online Publication Date: 3 February 2010

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This letter reports an acoustic resonator of high quality factors (Qs) operating in liquid media. The film bulk acoustic resonator (FBAR) is made of a ring-shaped piezoelectric aluminum nitride thin film, and is excited in a contour mode. By having a low motional resistance upon coupling with liquids, the contour mode FBAR achieved Qs up to 189, more than 12× over the state-of-the-art FBARs in liquids. The resonator was characterized by an aptamer—thrombin binding pair for a biosensor and showed a mass resolution of 1.78 ng/cm2.
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43.58.Kr Spectrum and frequency analyzers and filters; acoustical and electrical oscillographs; photoacoustic spectrometers; acoustical delay lines and resonators
77.84.Bw Elements, oxides, nitrides, borides, carbides, chalcogenides, etc.
77.55.hd AlN
43.58.-e Acoustical measurements and instrumentation

A simple strategy to realize biomimetic surfaces with controlled anisotropic wetting

Dong Wu, Qi-Dai Chen, Jia Yao, Yong-Chao Guan, Jian-Nan Wang, Li-Gang Niu, Hong-Hua Fang, and Hong-Bo Sun

Appl. Phys. Lett. 96, 053704 (2010); http://dx.doi.org/10.1063/1.3297881 (3 pages) | Cited 9 times

Online Publication Date: 5 February 2010

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The study of anisotropic wetting has become one of the most important research areas in biomimicry. However, realization of controlled anisotropic surfaces remains challenging. Here we investigated anisotropic wetting on grooves with different linewidth, period, and height fabricated by laser interference lithography and found that the anisotropy strongly depended on the height. The anisotropy significantly increased from 9° to 48° when the height was changed from 100 nm to 1.3 μm. This was interpreted by a thermodynamic model as a consequence of the increase of free energy barriers versus the height increase. According to the relationship, controlled anisotropic surfaces were rapidly realized by adjusting the grooves’ height that was simply accomplished by changing the resin thickness. Finally, the perpendicular contact angle was further enhanced to 131°±2° by surface modification, which was very close to 135°±3° of a common grass leaf.
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81.16.Nd Micro- and nanolithography
68.08.Bc Wetting
68.03.Cd Surface tension and related phenomena
68.35.Md Surface thermodynamics, surface energies

Facile fabrication and biological application of tin-rich indium tin oxide nanorods

Nitin Kumar, Omkar Parajuli, Man Feng, Jian Xu, and Jong-in Hahm

Appl. Phys. Lett. 96, 053705 (2010); http://dx.doi.org/10.1063/1.3309587 (3 pages) | Cited 2 times

Online Publication Date: 5 February 2010

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We demonstrate that one-dimensional indium tin oxide nanorods (ITO NRs) with high tin-incorporation ratio can be readily produced with a very good control over size and morphology using a gas-phase synthetic approach. Our current study presents a straightforward and facile growth route to synthesize ITO NRs with the atomic composition ratio of In:Sn:O (1:1:2). We further identified and assessed a promising potential application of these tin-rich InSnO2 NRs in biomolecular fluorescence assays. As-grown InSnO2 NRs showed a promising result for potential application in the fluorescence detection of protein molecules.
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81.07.Bc Nanocrystalline materials
68.65.-k Low-dimensional, mesoscopic, nanoscale and other related systems: structure and nonelectronic properties
61.46.Km Structure of nanowires and nanorods (long, free or loosely attached, quantum wires and quantum rods, but not gate-isolated embedded quantum wires)
87.15.mq Luminescence
87.14.E- Proteins
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