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Applied Physics Letters / Volume 96 / Issue 9 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 96, 093701 (2010); http://dx.doi.org/10.1063/1.3292216 (3 pages)

Four probe architecture using high spatial resolution single multi-walled carbon nanotube electrodes for electrophysiology and bioimpedance monitoring of whole tissue

Edward D. de Asis1,2, Joseph Leung3, Sally Wood1, and Cattien V. Nguyen2

1Departments of Electrical Engineering and Bioengineering, School of Engineering, Santa Clara University, 500 El Camino Real, Santa Clara, California 95053, USA
2ELORET Corporation, NASA Ames Research Center, M/S 229-1, Moffett Field, California 94035-1000, USA
3NASA Ames Research Center, Moffett Field, California 94035-1000, USA

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(Received 13 November 2009; accepted 21 December 2009; published online 3 March 2010)

We report the application of a sensor with a multielectrode architecture consisting of four single multiwalled carbon nanotube electrodes (sMWNT electrodes) with nanotube tip diameters of approximately 30 nm to stimulation, recording, and bioimpedance characterization of whole muscle. Parallel pairs of sMWNT electrodes achieve improved stimulation efficiency from a reduction in electrode impedance and enhanced signal-to-noise ratio by detecting endogenic signals from a larger population of electrically active cells. The sensor with a four sMWNT electrode configuration can monitor changes in whole tissue bioimpedance.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

bioelectric phenomena, biomedical electrodes, carbon nanotubes, cellular biophysics, electric impedance, electric impedance measurement, electric sensing devices, medical signal detection, muscle, nanobiotechnology

PACS

  • 87.85.Rs

    Nanotechnologies-applications

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 87.17.-d

    Cell processes

  • 87.19.Ff

    Muscles

  • 87.19.R-

    Mechanical and electrical properties of tissues and organs

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3292216

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    E. D. de Asis, Jr., J. Leung, S. Wood, and C. V. Nguyen, Appl. Phys. Lett. 95, 153701 (2009)APPLAB000095000015153701000001.


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