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13 Sep 2010

Volume 97, Issue 11, Articles (11xxxx)

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Appl. Phys. Lett. 97, 113701 (2010); http://dx.doi.org/10.1063/1.3487998 (3 pages)

Sarah E. Baker, Michael D. Pocha, Allan S. P. Chang, Donald J. Sirbuly, Stefano Cabrini, Scott D. Dhuey, Tiziana C. Bond, and Sonia E. Létant
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Detection of bio-organism simulants using random binding on a defect-free photonic crystal

Sarah E. Baker, Michael D. Pocha, Allan S. P. Chang, Donald J. Sirbuly, Stefano Cabrini, Scott D. Dhuey, Tiziana C. Bond, and Sonia E. Létant

Appl. Phys. Lett. 97, 113701 (2010); http://dx.doi.org/10.1063/1.3487998 (3 pages) | Cited 2 times

Online Publication Date: 13 September 2010

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The defect-free photonic crystal (PC) slab geometry was explored for size-selective detection of bio-organism simulants. Through feedback between finite-difference time-domain simulations and experiments, we generated a conservative limit of detection estimate for randomized pore filling of a two-dimensional PC slab, and predict that random binding affords the label-free PC-based optical detection of low numbers (of the order of 10) of biological particles.
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87.80.-y Biophysical techniques (research methods)
42.70.Qs Photonic bandgap materials
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
02.70.Bf Finite-difference methods

Early development of cutaneous cancer revealed by intravital nonlinear optical microscopy

Chun-Chin Wang (王俊欽), Feng-Chieh Li (李峰杰), Wei-Chou Lin (林維洲), Yang-Fang Chen (陳永芳), Shean-Jen Chen (陳顯禎), Sung-Jan Lin (林頌然), and Chen-Yuan Dong (董成淵)

Appl. Phys. Lett. 97, 113702 (2010); http://dx.doi.org/10.1063/1.3490644 (3 pages) | Cited 2 times

Online Publication Date: 16 September 2010

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We performed intravital multiphoton microscopy to image and analyze normal and carcinogen treated skin tissues of nude mice in vivo. Using intravital images and the quantitative pixel to pixel ratiometric processing of multiphoton autofluorescence to second harmonic generation index (MAFSI), we can visualize the interaction between epithelial cells and extracellular matrix. We found that as the imaging depth increases, MAFSI has different distribution in normal and treated cutaneous specimens. Since the treated skin eventually became squamous cell carcinoma, our results show that the physiological changes to mouse skin en route to become cancer can be effectively tracked by multiphoton microscopy.
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87.64.M- Optical microscopy
87.50.wf Biophysical mechanisms of interaction
87.19.xj Cancer
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