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20 Sep 2010

Volume 97, Issue 12, Articles (12xxxx)

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Appl. Phys. Lett. 97, 123101 (2010); http://dx.doi.org/10.1063/1.3490637 (3 pages)

Mark W. Licurse and Peter K. Davies
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Nanomechanical biosensing with immunomagnetic separation

Kutay Icoz and Cagri Savran

Appl. Phys. Lett. 97, 123701 (2010); http://dx.doi.org/10.1063/1.3489356 (3 pages)

Online Publication Date: 20 September 2010

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We report a biosensing method that combines immunomagnetic separation and nanomechanical detection. In this method, same magnetic beads that are used to “fish” biomolecules from complex mixtures enable deflection of a cantilever structure upon excitation by an oscillating magnetic field. Biotin-coated magnetic beads were used to capture and separate streptavidin from serum. Streptavidin loaded magnetic beads were exposed to a differential cantilever system whose sensing arm was functionalized with biotin. The magnetic force applied on the streptavidin-beads resulted in differential cantilever deflections that could be detected down to 0.26 Årms in air.
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87.80.-y Biophysical techniques (research methods)
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
07.10.Cm Micromechanical devices and systems
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.14.E- Proteins

Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices

Hu Tao, Sean M. Siebert, Mark A. Brenckle, Richard D. Averitt, Mark Cronin-Golomb, David L. Kaplan, and Fiorenzo G. Omenetto

Appl. Phys. Lett. 97, 123702 (2010); http://dx.doi.org/10.1063/1.3486157 (3 pages) | Cited 1 time

Online Publication Date: 21 September 2010

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In this paper, we report on gold nanoparticle (GNP) doped silk films as an implantable and degradable heating element activated by light, which can be potentially used for wireless powering of implanted microdevices. Proof-of-concept experiments have been conducted by casting a GNP doped silk film on a miniature thermal-power chip, which generates ∼ 20 mW when illuminated by a green laser with an output power of 450 mW/mm2 at 532 nm.
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87.85.Rs Nanotechnologies-applications
87.85.jj Biocompatibility
87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

Enzyme mediated synthesis of phytochelatin-capped CdS nanocrystals

Fang Liu, Seung Hyun Kang, Young-In Lee, Yong-ho Choa, Ashok Mulchandani, Nosang V. Myung, and Wilfred Chen

Appl. Phys. Lett. 97, 123703 (2010); http://dx.doi.org/10.1063/1.3485295 (3 pages) | Cited 1 time

Online Publication Date: 22 September 2010

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We reported the enzyme mediated synthesis of CdS nanocrystals by immobilized phytochelatin synthase, which converts glutathione into the metal-binding peptide phytochelatin (PC). Formation of CdS nanocrystals were observed upon the addition of CdCl2 and Na2S with PC as the capping agent. By varying the reaction times, different compositions of PCs (form PC2 to PC3) can be synthesized, resulting in the formation of highly stable nanocrystals with tunable sizes (from 2.0 to 1.6 nm diameter). This approach may be generalized to guide the in vitro self assembly of a wide range of nanocrystals with different compositions and sizes.
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81.07.Bc Nanocrystalline materials
87.85.J- Biomaterials
87.14.ej Enzymes
87.85.Rs Nanotechnologies-applications

Interferometric detection of mode splitting for whispering gallery mode biosensors

Joachim Knittel, Terry G. McRae, Kwan H. Lee, and Warwick P. Bowen

Appl. Phys. Lett. 97, 123704 (2010); http://dx.doi.org/10.1063/1.3494530 (3 pages) | Cited 10 times

Online Publication Date: 24 September 2010

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Sensors based on whispering gallery mode resonators can detect single nanoparticles and even single molecules. Particles attaching to the resonator induce a doublet in the transmission spectrum which provides a self-referenced detection signal. However, in practice this spectral feature is often obscured by the width of the resonance line which hides the doublet structure. This happens particularly in liquid environments that reduce the effective Q factor of the resonator. In this paper we demonstrate an interferometric setup that allows the direct detection of the hidden doublet and thus provides a pathway for developing practical sensor applications.
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87.85.fk Biosensors
84.40.Ua Telecommunications: signal transmission and processing; communication satellites
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