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27 Sep 2010

Volume 97, Issue 13, Articles (13xxxx)

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Appl. Phys. Lett. 97, 133303 (2010); http://dx.doi.org/10.1063/1.3491815 (3 pages)

Yoshihide Fujisaki, Yoshiki Nakajima, Daisuke Kumaki, Toshihiro Yamamoto, Shizuo Tokito, Takahiro Kono, Jun-ichi Nishida, and Yoshiro Yamashita
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Gd@Au15: A magic magnetic gold cluster for cancer therapy and bioimaging

Brahm Deo Yadav and Vijay Kumar

Appl. Phys. Lett. 97, 133701 (2010); http://dx.doi.org/10.1063/1.3491269 (3 pages) | Cited 5 times

Online Publication Date: 27 September 2010

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We report from ab initio calculations a magic magnetic cage cluster of gold, Gd@Au15, obtained by doping of a Gd atom in gold clusters. It has a highest occupied molecular orbital-lowest unoccupied molecular orbital gap of 1.31 eV within the generalized gradient approximation that makes it a potential candidate for cancer therapy with an additional attractive feature that its large magnetic moment of 7 μB could be beneficial for magnetic resonance imaging.
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36.40.Mr Spectroscopy and geometrical structure of clusters
36.40.Cg Electronic and magnetic properties of clusters
87.61.-c Magnetic resonance imaging
31.15.A- Ab initio calculations
87.85.J- Biomaterials

High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe

Xiang Li, Jiechen Yin, Changhong Hu, Qifa Zhou, K. Kirk Shung, and Zhongping Chen

Appl. Phys. Lett. 97, 133702 (2010); http://dx.doi.org/10.1063/1.3493659 (3 pages) | Cited 10 times

Online Publication Date: 27 September 2010

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We report an integrated ultrasound (US) and optical coherence tomography (OCT) probe and system for intravascular imaging. The dual-function probe is based on a 50 MHz focused ring US transducer, with a centric hole for mounting OCT probe. The coaxial US and light beams are steered by a 45° mirror to enable coregistered US/OCT imaging simultaneously. Lateral resolution of US is improved due to focused ultrasonic beam. Mirror effects on US were investigated and in vitro imaging of a rabbit aorta has been carried out. The combined US-OCT system demonstrated high resolution in visualizing superficial arterial structures while retaining deep penetration of ultrasonic imaging.
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43.35.Wa Biological effects of ultrasound, ultrasonic tomography
87.63.L- Visual imaging

Cross-validation of microfabricated atomic magnetometers with superconducting quantum interference devices for biomagnetic applications

Svenja Knappe, Tilmann H. Sander, Olaf Kosch, Frank Wiekhorst, John Kitching, and Lutz Trahms

Appl. Phys. Lett. 97, 133703 (2010); http://dx.doi.org/10.1063/1.3491548 (3 pages) | Cited 10 times

Online Publication Date: 28 September 2010

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We compare the performance of a chip-scale atomic magnetometer (CSAM) with that of a superconducting quantum interference device (SQUID) sensor in two biomedical applications. Magnetocardiograms (MCGs) of healthy human subjects were measured simultaneously by a CSAM and a multichannel SQUID sensor in a magnetically shielded room. The typical features of MCGs are resolved by the CSAM, matching the SQUID results. Magnetorelaxometry (MRX) signals of iron nanoparticles were also obtained with the CSAM and compared to similar measurements with a SQUID.
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85.25.Dq Superconducting quantum interference devices (SQUIDs)
07.55.Jg Magnetometers for susceptibility, magnetic moment, and magnetization measurements
07.55.Ge Magnetometers for magnetic field measurements
87.85.Va Micromachining
42.81.Pa Sensors, gyros

Third generation biosensing matrix based on Fe-implanted ZnO thin film

Shibu Saha, Vinay Gupta, K. Sreenivas, H. H. Tan, and C. Jagadish

Appl. Phys. Lett. 97, 133704 (2010); http://dx.doi.org/10.1063/1.3496456 (3 pages) | Cited 5 times

Online Publication Date: 1 October 2010

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Third generation biosensor based on Fe-implanted ZnO (Fe-ZnO) thin film has been demonstrated. Implantation of Fe in rf-sputtered ZnO thin film introduces redox center along with shallow donor level and thereby enhance its electron transfer property. Glucose oxidase (GOx), chosen as model enzyme, has been immobilized on the surface of the matrix. Cyclic voltammetry and photometric assay show that the prepared bioelectrode, GOx/Fe-ZnO/ITO/Glass is sensitive to the glucose concentration with enhanced response of 0.326 μA mM−1 cm−2 and low Km of 2.76 mM. The results show promising application of Fe-implanted ZnO thin film as an attractive matrix for third generation biosensing.
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87.80.-y Biophysical techniques (research methods)
87.15.R- Reactions and kinetics
87.15.ht Ultrafast dynamics; charge transfer
87.14.ej Enzymes
82.30.Fi Ion-molecule, ion-ion, and charge-transfer reactions
82.80.Fk Electrochemical methods
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