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1 Nov 2010

Volume 97, Issue 18, Articles (18xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 97, 183105 (2010); http://dx.doi.org/10.1063/1.3506485 (3 pages)

Z. H. Zhang, X. Q. Deng, X. Q. Tan, M. Qiu, and J. B. Pan
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Displacement of particles in microfluidics by laser-generated tandem bubbles

Jaclyn Lautz, Georgy Sankin, Fang Yuan, and Pei Zhong

Appl. Phys. Lett. 97, 183701 (2010); http://dx.doi.org/10.1063/1.3511538 (3 pages) | Cited 2 times

Online Publication Date: 3 November 2010

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The dynamic interaction between laser-generated tandem bubble and individual polystyrene particles of 2 and 10 μm in diameter is studied in a microfluidic channel (25 μm height) by high-speed imaging and particle image velocimetry. The asymmetric collapse of the tandem bubble produces a pair of microjets and associated long-lasting vortices that can propel a single particle to a maximum velocity of 1.4 m/s in 30 μs after the bubble collapse with a resultant directional displacement up to 60 μm in 150 μs. This method may be useful for high-throughput cell sorting in microfluidic devices.
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47.85.Np Fluidics
47.32.-y Vortex dynamics; rotating fluids
47.55.D- Drops and bubbles
47.60.Dx Flows in ducts and channels
47.60.Kz Flows and jets through nozzles
47.61.Jd Multiphase flows
47.80.Jk Flow visualization and imaging

Ambient molecular water accumulation on silica surfaces detected by a reflectance interference optical balance

Xuefeng Wang, Ming Zhao, and David D. Nolte

Appl. Phys. Lett. 97, 183702 (2010); http://dx.doi.org/10.1063/1.3505320 (3 pages)

Online Publication Date: 3 November 2010

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Water is a persistent background in virtually all biosensors, yet is difficult to quantify. We apply an interferometric optical balance to measure water film accumulation from air onto several types of prepared silica surfaces. The optical balance uses in-line common-path interferometry with balanced quadratures to measure the real-time accumulation of molecular films. The accumulated water thickness is sensitive to ambient conditions, with thicknesses that vary from picometers up to nanometers, even on hydrophobic silanized surfaces. These results demonstrate that water adsorption contributes an excess signal in dry label-free protein microarray optical biosensors and presents a fundamental limit to assay sensitivity.
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68.43.Mn Adsorption kinetics
78.20.-e Optical properties of bulk materials and thin films
87.80.-y Biophysical techniques (research methods)
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

Characterization of corneal damage from Pseudomonas aeruginosa infection by the use of multiphoton microscopy

Yu-Lin Chang (張鈺林), Wei-Liang Chen (陳維良), Wen Lo (駱文), Shean-Jen Chen (陳顯禎), Hsin-Yuan Tan (譚欣媛), and Chen-Yuan Dong (董成淵)

Appl. Phys. Lett. 97, 183703 (2010); http://dx.doi.org/10.1063/1.3505360 (3 pages)

Online Publication Date: 3 November 2010

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Using multiphoton autofluorescence (MAF) and second harmonic generation (SHG) microscopy, we investigate the morphology and the structure of the corneal epithelium and stroma collagen of bovine cornea following injection of Pseudomonas aeruginosa. We found that corneal epithelial cells are damaged and stromal collagen becoming increasingly autofluorescent with time. We also characterized infected cornea cultured for 0, 6, 12, and 24 h by quantitative ratiometric MAF to SHG index (MAFSI) analysis. MAFSI results show that the destruction of the stromal collagen corresponds to a decrease in SHG intensity and increase of MAF signal with time.
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42.66.Ct Anatomy and optics of eye
87.19.lt Sensory systems: visual, auditory, tactile, taste, and olfaction
87.64.mn Multiphoton
87.19.xb Bacterial diseases
87.17.-d Cell processes
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