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29 Nov 2010

Volume 97, Issue 22, Articles (22xxxx)

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Appl. Phys. Lett. 97, 223101 (2010); http://dx.doi.org/10.1063/1.3519844 (3 pages)

Jin-Kyu Yang, Svetlana V. Boriskina, Heeso Noh, Michael J. Rooks, Glenn S. Solomon, Luca Dal Negro, and Hui Cao
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High frequency asynchronous magnetic bead rotation for improved biosensors

Paivo Kinnunen, Irene Sinn, Brandon H. McNaughton, and Raoul Kopelman

Appl. Phys. Lett. 97, 223701 (2010); http://dx.doi.org/10.1063/1.3505492 (3 pages) | Cited 3 times

Online Publication Date: 29 November 2010

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Biosensors with increasingly high sensitivity are crucial for probing small scale properties. The asynchronous magnetic bead rotation (AMBR) sensor is an emerging sensor platform, based on magnetically actuated rotation. Here the frequency dependence of the AMBR sensor’s sensitivity is investigated. An asynchronous rotation frequency of 145 Hz is achieved. This increased frequency will allow for a calculated detection limit of as little as a 59 nm change in bead diameter, which is a dramatic improvement over previous AMBR sensors and further enables physical and biomedical applications.
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87.85.-d Biomedical engineering
87.80.-y Biophysical techniques (research methods)

In vivo and simultaneous multimodal imaging: Integrated multiplex coherent anti-Stokes Raman scattering and two-photon microscopy

Dong Li, Wei Zheng, Yan Zeng, and Jianan Y. Qu

Appl. Phys. Lett. 97, 223702 (2010); http://dx.doi.org/10.1063/1.3521415 (3 pages)

Online Publication Date: 29 November 2010

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Simultaneous multimodal imaging is critical for in vivo study of biological dynamic processes and clinical applications. In this study, we demonstrate a multimodal nonlinear optical (NLO) microscopy of the capability to simultaneously produce images of multiplex coherent anti-Stokes Raman scattering (M-CARS), two-photon excitation fluorescence, and second harmonic generation in living biological systems. The excitation sources are a femtosecond Ti:sapphire laser and a broadband supercontinuum generated from a photonic crystal fiber. The simultaneously excited multiple NLO signals were recorded by using a time- and wavelength-resolved detection technique. In M-CARS imaging, the nonresonant background is effectively reduced by using a simple background subtraction method.
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78.47.jh Coherent nonlinear optical spectroscopy
87.63.Hg Thermography
42.65.Ky Frequency conversion; harmonic generation, including higher-order harmonic generation
42.65.Re Ultrafast processes; optical pulse generation and pulse compression

Study of single particle charge and Brownian motions with surface plasmon resonance

Xiaonan Shan, Shaopeng Wang, and Nongjian Tao

Appl. Phys. Lett. 97, 223703 (2010); http://dx.doi.org/10.1063/1.3519364 (3 pages)

Online Publication Date: 30 November 2010

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We demonstrated a method to accurately measure the zeta potentials and surface charges of individual particles by surface plasmon resonance microscopy (SPRM). The principle is based on the sensitive dependence of surface plasmons in a metal surface on the distance between a particle and the surface. By applying a periodic (ac) electric field to the metal surface, the charged particle oscillates, which is measured with SPRM, from which the zeta potential and the surface charge of the particle can be determined. The ac method reduces the electro-osmotic effect and noises induced by Brownian motions and allows for the rapid determination of the zeta potentials of individual particles.
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73.20.Mf Collective excitations (including excitons, polarons, plasmons and other charge-density excitations)
82.45.Jn Surface structure, reactivity and catalysis
05.40.Jc Brownian motion
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Resonant waveguide grating imager for live cell sensing

Ann M. Ferrie, Qi Wu, and Ye Fang

Appl. Phys. Lett. 97, 223704 (2010); http://dx.doi.org/10.1063/1.3522894 (3 pages) | Cited 3 times

Online Publication Date: 1 December 2010

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We report on a resonant waveguide grating imager for high throughput screening using live cells. This imager can generate a snapshot image of all biosensors in a 384-well microtiter plate with a time resolution of ∼ 3 s and a spatial resolution of 80 μm. This imager is well tolerant to variability in plate configurations and cell confluency. The resonant wavelength and its shifts induced by cell responses at each pixel correlate well with cell confluency. Data filtration protocol can be used to improve assay quality for partially confluent cells.
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87.80.-y Biophysical techniques (research methods)
87.17.-d Cell processes
42.79.Dj Gratings
42.79.Pw Imaging detectors and sensors
42.79.Gn Optical waveguides and couplers
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