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6 Dec 2010

Volume 97, Issue 23, Articles (23xxxx)

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Appl. Phys. Lett. 97, 233101 (2010); http://dx.doi.org/10.1063/1.3523252 (3 pages)

Hoonkyung Lee, Marvin L. Cohen, and Steven G. Louie
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Valve-based microfluidic device for droplet on-demand operation and static assay

Feng Guo, Kan Liu, Xing-Hu Ji, Hui-Jiang Ding, Meng Zhang, Qian Zeng, Wei Liu, Shi-Shang Guo, and Xing-Zhong Zhao

Appl. Phys. Lett. 97, 233701 (2010); http://dx.doi.org/10.1063/1.3521283 (3 pages) | Cited 1 time

Online Publication Date: 6 December 2010

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A valve-based microfluidic device was developed for droplet on-demand operation and static assay. Droplet generation with precise and expectant volume, transportation, fusion, and trapping was achieved by integration of microvalves with programed control. Based on this automatic unique function combination, a droplet team was created with a controllable proportion of components. A DNA sample was encapsulated into the aqueous droplets, selectively merged with probe droplet in the desired ratio, well mixed, and then trapped for the static fluorescence assay with a total reagent consumption of no more than 2 μl. This method would have a powerful potential for biochemical or chemical research.
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85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
47.85.Np Fluidics
47.61.Fg Flows in micro-electromechanical systems (MEMS) and nano-electromechanical systems (NEMS)
87.80.Ek Mechanical and micromechanical techniques
87.14.gk DNA
47.55.db Drop and bubble formation

Nanoelectronic detection of breast cancer biomarker

Yu Chen, Xihua Wang, Mi K. Hong, Carol L. Rosenberg, Björn M. Reinhard, Shyamsunder Erramilli, and Pritiraj Mohanty

Appl. Phys. Lett. 97, 233702 (2010); http://dx.doi.org/10.1063/1.3519983 (3 pages) | Cited 1 time

Online Publication Date: 8 December 2010

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There is a fundamental need for semiconductor-based ultrasensitive nanosensors for detecting heterogeneous biomarkers associated with cancer, which do not have a well-defined molecular weight. Here we show that a nanoscale gated biological field effect transistor can be used for detecting the breast cancer serum biomarker protein CA15.3 down to levels of concentration less than 20 units/ml, relevant for clinical use. Our work extends the capability of nanowire sensors to a class of mucin-based heterogeneous protein biomarkers that are of fundamental importance to modern cancer detection.
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87.85.Rs Nanotechnologies-applications
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
85.30.Tv Field effect devices
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
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