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27 Dec 2010

Volume 97, Issue 26, Articles (26xxxx)

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Appl. Phys. Lett. 97, 263701 (2010); http://dx.doi.org/10.1063/1.3530124 (3 pages)

Shu-Hsien Liao, Kai-Wen Huang, Hong-Chang Yang, Chang-Te Yen, M. J. Chen, Hsin-Hsien Chen, Herng-Er Horng, and Shieh Yueh Yang
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Characterization of tumors using high-Tc superconducting quantum interference device-detected nuclear magnetic resonance and imaging

Shu-Hsien Liao, Kai-Wen Huang, Hong-Chang Yang, Chang-Te Yen, M. J. Chen, Hsin-Hsien Chen, Herng-Er Horng, and Shieh Yueh Yang

Appl. Phys. Lett. 97, 263701 (2010); http://dx.doi.org/10.1063/1.3530124 (3 pages) | Cited 8 times

Online Publication Date: 28 December 2010

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The characterization of cancerous livers in rats using nuclear magnetic resonance and magnetic resonance imaging (NMR/MRI) based on high-Tc superconducting quantum interference devices (SQUIDs) is presented. The T1−1 were observed to be 6.5±0.5 s−1 for controlled livers and 2.85±0.2 s−1 for cancerous livers, which indicate that the T1 can be used to distinguish the cancerous tissues from controlled liver tissues. The intensity ratio for tap water, cancerous tissue, and controlled tissue, respectively, is 1:1.15:0.56 at TBp = 1 s. The SQUID-detected NMR/MRI exhibits potential applications in research and clinics.
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87.61.Tg Clinical applications
87.19.xj Cancer
87.85.Pq Biomedical imaging

Biological cell controllable patch-clamp microchip

Siva Penmetsa, Krithika Nagrajan, Zhongcheng Gong, David Mills, and Long Que

Appl. Phys. Lett. 97, 263702 (2010); http://dx.doi.org/10.1063/1.3532094 (3 pages)

Online Publication Date: 28 December 2010

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A patch-clamp (PC) microchip with cell sorting and positioning functions is reported, which can avoid drawbacks of random cell selection or positioning for a PC microchip. The cell sorting and positioning are enabled by air bubble (AB) actuators. AB actuators are pneumatic actuators, in which air pressure is generated by microheaters within sealed microchambers. The sorting, positioning, and capturing of 3T3 cells by this type of microchip have been demonstrated. Using human breast cancer cells MDA-MB-231 as the model, experiments have been demonstrated by this microchip as a label-free technical platform for real-time monitoring of the cell viability.
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87.17.-d Cell processes
87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
47.85.Kn Hydraulic and pneumatic machinery
87.19.xj Cancer

Glycoprotein mucin molecular brush on cancer cell surface acting as mechanical barrier against drug delivery

Xin Wang, Aalok A. Shah, Robert B. Campbell, and Kai-tak Wan

Appl. Phys. Lett. 97, 263703 (2010); http://dx.doi.org/10.1063/1.3532847 (3 pages)

Online Publication Date: 28 December 2010

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Uptake of cytotoxic drugs by typical tumor cells is limited by the dense dendritic network of oligosaccharide mucin chains that forms a mechanical barrier. Atomic force microscopy is used to directly measure the force needed to pierce the mucin layer to reach the cell surface. Measurements are analyzed by de Gennes’ steric reptation theory. Multidrug resistant ovarian tumor cells shows significantly larger penetration load compared to the wide type. A pool of pancreatic, lung, colorectal, and breast cells are also characterized. The chemotherapeutic agent, benzyl-α-GalNac, for inhibiting glycosylation is shown to be effective in reducing the mechanical barrier.
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87.85.Pq Biomedical imaging
87.64.Dz Scanning tunneling and atomic force microscopy
87.14.E- Proteins
87.19.xj Cancer
87.17.Rt Cell adhesion and cell mechanics
87.15.R- Reactions and kinetics

Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles

Mainul Hossain, Chaoming Wang, and Ming Su

Appl. Phys. Lett. 97, 263704 (2010); http://dx.doi.org/10.1063/1.3533817 (3 pages)

Online Publication Date: 30 December 2010

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Multiple DNA and protein biomarkers have been detected based on characteristic x-ray fluorescence of a panel of metal and alloy nanoparticles, which are modified with ligands of biomarkers to create a one-to-one correspondence and immobilized on ligand-modified substrates after forming complexes with target biomarkers in three-strand or sandwich configuration. By determining the presence and concentration of nanoparticles using x-ray fluorescence, the nature and amount of biomarkers can be detected with limits of 1 nM for DNA and 1 ng/ml for protein. By combining high penetrating ability of x-rays, this method allows quantitative imaging of multiple biomarkers.
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87.59.-e X-ray imaging
87.85.J- Biomaterials
87.85.Rs Nanotechnologies-applications
87.14.E- Proteins
87.14.gk DNA
87.15.-v Biomolecules: structure and physical properties
87.57.-s Medical imaging
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