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Applied Physics Letters / Volume 97 / Issue 4 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 97, 043702 (2010); http://dx.doi.org/10.1063/1.3467833 (3 pages)

Giant magnetoimpedance-based microchannel system for quick and parallel genotyping of human papilloma virus type 16/18

Hao Yang1, Lei Chen1, Chong Lei1, Ju Zhang2, Ding Li3, Zhi-Min Zhou1, Chen-Chen Bao1, Heng-Yao Hu1, Xiang Chen1, Feng Cui1, Shuang-Xi Zhang1, Yong Zhou1, and Da-Xiang Cui1

1Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Dong Chuan Road 800, Shanghai 200240, People's Republic of China
2Institute of Gene Diagnosis, State Key Laboratory of Cancer Biology, Fourth Military Medical University, 17 Changle West Road, Xian, Shanxi 710032, People's Republic of China
3Center of Biological Diagnosis and Therapy, No. 261 Hospital of PLA, Beijing 100094, People’s Republic of China

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(Received 28 April 2010; accepted 1 July 2010; published online 26 July 2010)

Quick and parallel genotyping of human papilloma virus (HPV) type 16/18 is carried out by a specially designed giant magnetoimpedance (GMI) based microchannel system. Micropatterned soft magnetic ribbon exhibiting large GMI ratio serves as the biosensor element. HPV genotyping can be determined by the changes in GMI ratio in corresponding detection region after hybridization. The result shows that this system has great potential in future clinical diagnostics and can be easily extended to other biomedical applications based on molecular recognition.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomedical equipment, bioMEMS, biosensors, giant magnetoresistance, magnetoresistive devices, microchannel flow, microorganisms, soft magnetic materials

PACS

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 85.75.-d

    Magnetoelectronics; spintronics: devices exploiting spin polarized transport or integrated magnetic fields

  • 85.70.Kh

    Magnetic thin film devices: magnetic heads (magnetoresistive, inductive, etc.); domain-motion devices, etc.

  • 87.80.Ek

    Mechanical and micromechanical techniques

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3467833

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    A. Kumar, S. Mohapatra, V. F. Miyar, A. Cerdeira, J. A. Garcia, H. Srikanth, J. Gass, and G. V. Kurlyandskaya, Appl. Phys. Lett. 91, 143902 (2007)APPLAB000091000014143902000001.


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