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16 Aug 2010

Volume 97, Issue 7, Articles (07xxxx)

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Appl. Phys. Lett. 97, 073101 (2010); http://dx.doi.org/10.1063/1.3478515 (3 pages)

Hon-Way Lin (林弘偉), Yu-Jung Lu (呂宥蓉), Hung-Ying Chen (陳虹穎), Hong-Mao Lee (李弘貿), and Shangjr Gwo (果尚志)
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Modeling the sustained release of lipophilic drugs from liposomes

Like Zeng and Xiaoyi Wu

Appl. Phys. Lett. 97, 073701 (2010); http://dx.doi.org/10.1063/1.3479924 (3 pages) | Cited 5 times

Online Publication Date: 17 August 2010

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The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.
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47.63.mh Transport processes and drug delivery
87.17.-d Cell processes
87.16.D- Membranes, bilayers, and vesicles
47.63.-b Biological fluid dynamics

A charge pumping technique to identify biomolecular charge polarity using a nanogap embedded biotransistor

Sungho Kim, Jee-Yeon Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi

Appl. Phys. Lett. 97, 073702 (2010); http://dx.doi.org/10.1063/1.3473819 (3 pages)

Online Publication Date: 19 August 2010

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Charge pumping technique is investigated to identify biomolecular charge polarity using a nanogap-embedded biotransistor. Biomolecules immobilized in a nanogap provide additional charges in the gate dielectric. They give rise to a change in the charge pumping current, as detected by applying a designed pulse waveform. The measured results are analyzed with the aid of numerical simulations. The proposed charge pumping technique represents an insightful method of investigating the electrical properties of biomolecules beyond biosensing.
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85.65.+h Molecular electronic devices
85.30.Tv Field effect devices

A breathing rate sensor with plastic optical fiber

Lipi Mohanty and Kevin S. C. Kuang

Appl. Phys. Lett. 97, 073703 (2010); http://dx.doi.org/10.1063/1.3480601 (3 pages) | Cited 1 time

Online Publication Date: 19 August 2010

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A breathing rate sensor has been developed using plastic optical fiber and the test results are presented in this letter. The principle of coupling loss was used in designing this sensor to take advantage of the large core size of plastic optic fiber. The sensor was placed near the nostril to determine the rate of breathing as air was exhaled. The results demonstrated the ability to quantify the breathing rate and monitor different breathing patterns up to a resolution of 1 breath/s (1 Hz).
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87.19.Wx Pneumodyamics, respiration
87.63.L- Visual imaging
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