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Applied Physics Letters / Volume 97 / Issue 9 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 97, 093701 (2010); http://dx.doi.org/10.1063/1.3484958 (3 pages)

Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating

Humeyra Caglayan1, Semih Cakmakyapan1, Sarah A. Addae2, Melissa A. Pinard2, Deniz Caliskan1, Kadir Aslan2, and Ekmel Ozbay1

1Department of Physics, Department of Electrical and Electronics Engineering, Nanotechnology Research Center-NANOTAM, Bilkent University, Bilkent, 06800 Ankara, Turkey
2Department of Chemistry, Morgan State University, Baltimore, Maryland 21251, USA

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(Received 13 May 2010; accepted 5 August 2010; published online 30 August 2010)

In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

biosensors, microwave heating, molecular biophysics, proteins, resonators

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 87.15.-v

    Biomolecules: structure and physical properties

  • 87.14.E-

    Proteins

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3484958

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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