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Applied Physics Letters / Volume 97 / Issue 9 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 97, 093704 (2010); http://dx.doi.org/10.1063/1.3481695 (3 pages)

Lab-on-a-chip flow cytometer employing color-space-time coding

Sung Hwan Cho1, Wen Qiao2, Frank S. Tsai2, Kenichi Yamashita3, and Yu-Hwa Lo1,2

1Materials Science and Engineering Program, University of California at San Diego, La Jolla, California 92093–0418, USA
2Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, California 92093–0407, USA
3National Institute of Advanced Industrial Science and Technology (AIST), 807–1, Saga 841–0052, Japan

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(Received 5 July 2010; accepted 2 August 2010; published online 2 September 2010)

We describe a fluorescent detection technique for a lab-on-a-chip flow cytometer. Fluorescent emission is encoded into a time-dependent signal as a fluorescent cell or bead traverses a waveguide array with integrated spatial filters and color filters. Different from conventional colored filters with well-defined transmission spectral window, the integrated color filters are designed to have broad transmission characteristics, similar to the red-green-blue photoreceptors in the retina of human eye. This unique design allows us to detect multiple fluorescent colors with only three color filters based on the technique of color-space-time coding using only one single photomultiplier tube or avalanche photodetector.

© 2010 American Institute of Physics

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KEYWORDS and PACS

Keywords

avalanche photodiodes, cellular biophysics, flow measurement, fluorescence, lab-on-a-chip, optical filters, photodetectors, photomultipliers, space-time codes, spatial filters

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 47.85.-g

    Applied fluid mechanics

  • 87.17.-d

    Cell processes

  • 85.60.Ha

    Photomultipliers; phototubes and photocathodes

  • 47.80.-v

    Instrumentation and measurement methods in fluid dynamics

  • 42.79.Ci

    Filters, zone plates, and polarizers

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3481695

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    J. Godin, V. Lien, and Y. -H. Lo, Appl. Phys. Lett. 89, 061106 (2006)APPLAB000089000006061106000001.


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