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7 Mar 2011

Volume 98, Issue 10, Articles (10xxxx)

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Appl. Phys. Lett. 98, 104101 (2011); http://dx.doi.org/10.1063/1.3560505 (3 pages)

Zhongchang Wang, Susumu Tsukimoto, Rong Sun, Mitsuhiro Saito, and Yuichi Ikuhara
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Electron paramagnetic resonance study of unpaired electron species in thin films of pyrimidine bases induced by nitrogen and oxygen K-shell photoabsorption

T. Oka, A. Yokoya, and K. Fujii

Appl. Phys. Lett. 98, 103701 (2011); http://dx.doi.org/10.1063/1.3563712 (3 pages) | Cited 3 times

Online Publication Date: 10 March 2011

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In order to clarify the mechanism of DNA-base modification induced by K-shell photoabsorption of nitrogen and oxygen atoms, we measured electron paramagnetic resonance (EPR) spectra of two DNA pyrimidine bases, thymine, and cytosine. The g-factor of 2.000 of the unpaired electron species arising only during irradiation is determined. The EPR intensities for cytosine are two times larger than those simply estimated based on the photoabsorption cross section, whereas those for thymine show similar energy dependence to photoabsorption spectra, suggesting that cytosine favors to form unpaired electron species, rather than thymine, presumably due to the excitation of the enhanced electron capturing.
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87.80.Lg Magnetic and paramagnetic resonance
87.14.gk DNA
87.15.R- Reactions and kinetics

Excellent biocompatibility of semiconductor quantum dots encased in multifunctional poly(N-isopropylacrylamide) nanoreservoirs and nuclear specific labeling of growing neurons

Somesree GhoshMitra, David R. Diercks, Nathaniel C. Mills, DiAnna L. Hynds, and Santaneel Ghosh

Appl. Phys. Lett. 98, 103702 (2011); http://dx.doi.org/10.1063/1.3562036 (3 pages) | Cited 3 times

Online Publication Date: 11 March 2011

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Quantum dots (QDs) have received attention for labeling biomolecules; however, toxicity of these nanostructures in the intracellular environment has prevented a biomedical breakthrough. Here we report biocompatibility of a QD based multifunctional system on neuronal cells. Moreover, the designed nanostructures bind with high affinity in the cell nucleus. Nucleus specific binding and enhanced biocompatibility, coupled with no deleterious effects on neurite outgrowth, even at high dosages (500 μg/ml sphere conc.) suggest increased therapeutic potential of this system for specific targeting followed by controlled release of drugs in treating neurodegenerative disorders.
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87.85.J- Biomaterials
87.85.Rs Nanotechnologies-applications
87.85.D- Applied neuroscience
87.19.X- Diseases
87.17.-d Cell processes
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