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25 Apr 2011

Volume 98, Issue 17, Articles (17xxxx)

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Appl. Phys. Lett. 98, 171102 (2011); http://dx.doi.org/10.1063/1.3582035 (3 pages)

Shigeru Nakayama, Satomi Ishida, Satoshi Iwamoto, and Yasuhiko Arakawa
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Whole field decoupling of predistortion on polymeric cell force transducer

Xiaoyu Zheng and Xin Zhang

Appl. Phys. Lett. 98, 173701 (2011); http://dx.doi.org/10.1063/1.3579248 (3 pages)

Online Publication Date: 25 April 2011

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Microfabricated polymer transducers have been developed to study cell mechanics. The key principle is to quantify the deformations on the sensor arrays induced by cell contractions and convert them into force distributions. The simplifications in deformation measurements come from the basic assumption that the deformation is solely attributed to cell contractions triggered by chemical or electrical stimuli. The diffraction moiré fringes via two polymer gratings provide whole field evolutions of distortion/strain on soft-lithography fabricated substrates. We found that the moiré patterns are able to decouple predistortions which were traditionally thought to be solely caused by cell contractile forces.
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87.80.-y Biophysical techniques (research methods)
07.10.Pz Instruments for strain, force, and torque
87.17.Rt Cell adhesion and cell mechanics
07.07.Mp Transducers

ZnO thin film transistor immunosensor with high sensitivity and selectivity

Pavel Ivanoff Reyes, Chieh-Jen Ku, Ziqing Duan, Yicheng Lu, Aniruddh Solanki, and Ki-Bum Lee

Appl. Phys. Lett. 98, 173702 (2011); http://dx.doi.org/10.1063/1.3582555 (3 pages) | Cited 2 times

Online Publication Date: 29 April 2011

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A zinc oxide thin film transistor-based immunosensor (ZnO-bioTFT) is presented. The back-gate TFT has an on-off ratio of 108 and a threshold voltage of 4.25 V. The ZnO channel surface is biofunctionalized with primary monoclonal antibodies that selectively bind with epidermal growth factor receptor (EGFR). Detection of the antibody-antigen reaction is achieved through channel carrier modulation via pseudo double-gating field effect caused by the biochemical reaction. The sensitivity of 10 fM detection of pure EGFR proteins is achieved. The ZnO-bioTFT immunosensor also enables selectively detecting 10 fM of EGFR in a 5 mg/ml goat serum solution containing various other proteins.
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07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
85.30.Tv Field effect devices
87.14.E- Proteins
87.15.R- Reactions and kinetics
87.80.-y Biophysical techniques (research methods)
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