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14 Feb 2011

Volume 98, Issue 7, Articles (07xxxx)

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Appl. Phys. Lett. 98, 073101 (2011); http://dx.doi.org/10.1063/1.3554360 (3 pages)

Wei Xu, Rajesh Leeladhar, Yao-Tsan Tsai, Eui-Hyeok Yang, and Chang-Hwan Choi
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Atmospheric-pressure plasma-jet from micronozzle array and its biological effects on living cells for cancer therapy

Kangil Kim, Jae Duk Choi, Yong Cheol Hong, Geunyoung Kim, Eun Joo Noh, Jong-Soo Lee, and Sang Sik Yang

Appl. Phys. Lett. 98, 073701 (2011); http://dx.doi.org/10.1063/1.3555434 (3 pages) | Cited 5 times

Online Publication Date: 14 February 2011

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We propose a plasma-jet device with a micrometer-sized nozzle array for use in a cancer therapy. Also, we show the biological effects of atmospheric-pressure plasma on living cells. Nitrogen-plasma activated a surrogate DNA damage signal transduction pathway, called the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 pathway, suggesting that the nitrogen-plasma generates DNA double-strand breaks. Phosphorylation of H2AX and p53 was detected in the plasma-treated cells, leading to apoptotic cell death. Thus, an effect for the nitrogen plasma in the control of apoptotic cell death provides insight into the how biological effects of the nitrogen-plasma can be applied to the control of cell survival, a finding with potential therapeutic implications.
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87.56.-v Radiation therapy equipment
87.18.Mp Signal transduction networks
87.19.xj Cancer
52.75.-d Plasma devices
52.77.-j Plasma applications

On-chip measurement of the Brownian relaxation frequency of magnetic beads using magnetic tunneling junctions

M. Donolato, E. Sogne, B. T. Dalslet, M. Cantoni, D. Petti, J. Cao, F. Cardoso, S. Cardoso, P. P. Freitas, M. F. Hansen, and R. Bertacco

Appl. Phys. Lett. 98, 073702 (2011); http://dx.doi.org/10.1063/1.3554374 (3 pages) | Cited 4 times

Online Publication Date: 15 February 2011

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We demonstrate the detection of the Brownian relaxation frequency of 250 nm diameter magnetic beads using a lab-on-chip platform based on current lines for exciting the beads with alternating magnetic fields and highly sensitive magnetic tunnel junction (MTJ) sensors with a superparamagnetic free layer. The first harmonic out-of-phase component of the MTJ response gives the imaginary part of the magnetic bead susceptibility, which peaks at the Brownian relaxation frequency. This work paves the way to on-chip implementation of Brownian magnetorelaxometry in innovative “lab-on-a-bead” assays for biomolecular recognition.
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07.55.-w Magnetic instruments and components
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
87.80.Lg Magnetic and paramagnetic resonance

Aptamer-modified anodized aluminum oxide-based capacitive sensor for the detection of bisphenol A

Bongkeun Kang, Joo Hyoung Kim, Soyoun Kim, and Kyung-Hwa Yoo

Appl. Phys. Lett. 98, 073703 (2011); http://dx.doi.org/10.1063/1.3555345 (3 pages) | Cited 2 times

Online Publication Date: 16 February 2011

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We describe a rapid, sensitive, and low-cost method to detect bisphenol A (BPA) using an anodized aluminum oxide-based capacitive sensor. BPA is detected by measuring the change in capacitance caused by the biospecific binding of BPA with a BPA aptamer that is immobilized on the electrode surface. For a solution containing 100 pM BPA, the capacitance decreased by approximately 3%. In addition, we fabricated a capacitive sensor array and demonstrated that BPA in environmental samples can be measured using our capacitive sensor.
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07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

Nanostructured glucose-oxidase immobilized SnO2 thin films for glucose sensing

S. Dhobale, P. Joshee, G. Deore, S. L. Laware, and S. N. Kale

Appl. Phys. Lett. 98, 073704 (2011); http://dx.doi.org/10.1063/1.3555460 (3 pages)

Online Publication Date: 16 February 2011

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Polycrystalline rutile films of SnO2 ( ∼ 1500 Å) were deposited on Al2O3. Film imaging showed regular ellipsoidal nanostructured growth. Different concentrations (1000–3000 U) of glucose oxidase (GOx) were immobilized on SnO2 surface. Upon interaction with various glucose concentrations (65–300 mg/dl), films showed pronounced change in their sheet resistance with recovery and repeatability. Nanostructured SnO2 surfaces probably enhance adsorption of oxygen moieties. These convert to their ions by extracting electron/s from the conduction band of SnO2, which further interacts with H+, formed during the GOx-glucose interaction. This releases the trapped electron to the conduction band of SnO2, justifying its role as a catalyst.
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68.55.-a Thin film structure and morphology
68.43.Mn Adsorption kinetics
82.65.+r Surface and interface chemistry; heterogeneous catalysis at surfaces
73.22.-f Electronic structure of nanoscale materials and related systems
61.46.-w Structure of nanoscale materials
87.85.Rs Nanotechnologies-applications
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