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26 Sep 2011

Volume 99, Issue 13, Articles (13xxxx)

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Appl. Phys. Lett. 99, 131101 (2011); http://dx.doi.org/10.1063/1.3641907 (3 pages)

Linas Minkevičius, Vincas Tamošiūnas, Irmantas Kašalynas, Dalius Seliuta, Gintaras Valušis, Alvydas Lisauskas, Sebastian Boppel, Hartmut G. Roskos, and Klaus Köhler
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Single-walled carbon nanotubes and nanocrystalline graphene reduce beam-induced movements in high-resolution electron cryo-microscopy of ice-embedded biological samples

Daniel Rhinow, Nils-Eike Weber, Andrey Turchanin, Armin Gölzhäuser, and Werner Kühlbrandt

Appl. Phys. Lett. 99, 133701 (2011); http://dx.doi.org/10.1063/1.3645010 (3 pages) | Cited 2 times

Online Publication Date: 27 September 2011

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For single particle electron cryo-microscopy (cryoEM), contrast loss due to beam-induced charging and specimen movement is a serious problem, as the thin films of vitreous ice spanning the holes of a holey carbon film are particularly susceptible to beam-induced movement. We demonstrate that the problem is at least partially solved by carbon nanotechnology. Doping ice-embedded samples with single-walled carbon nanotubes (SWNT) in aqueous suspension or adding nanocrystalline graphene supports, obtained by thermal conversion of cross-linked self-assembled biphenyl precursors, significantly reduces contrast loss in high-resolution cryoEM due to the excellent electrical and mechanical properties of SWNTs and graphene.
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87.80.-y Biophysical techniques (research methods)
82.70.Kj Emulsions and suspensions
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