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17 Oct 2011

Volume 99, Issue 16, Articles (16xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 99, 163301 (2011); http://dx.doi.org/10.1063/1.3651509 (3 pages)

Jonathan E. Allen, Kevin G. Yager, Htay Hlaing, Chang-Yong Nam, Benjamin M. Ocko, and Charles T. Black
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In-situ guidance of individual neuronal processes by wet femtosecond-laser processing of self-assembled monolayers

Hideaki Yamamoto, Kazunori Okano, Takanori Demura, Yoichiroh Hosokawa, Hiroshi Masuhara, Takashi Tanii, and Shun Nakamura

Appl. Phys. Lett. 99, 163701 (2011); http://dx.doi.org/10.1063/1.3651291 (3 pages) | Cited 3 times

Online Publication Date: 17 October 2011

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In-situ guidance of neuronal processes (neurites) is demonstrated by applying wet femtosecond-laser processing to an organosilane self-assembled monolayer (SAM) template. By scanning focused laser beam between cell adhesion sites, on which primary neurons adhered and extended their neurites, we succeeded in guiding the neurites along the laser-scanning line. This guidance was accomplished by multiphoton laser ablation of cytophobic SAM layer and subsequent adsorption of cell adhesion molecule, laminin, onto the ablated region. This technique allows us to arbitrarily design neuronal networks in vitro.
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87.63.lt Laser imaging
87.85.G- Biomechanics
87.17.-d Cell processes

Thermal conductivity of bovine serum albumin: A tool to probe denaturation of protein

Byoung Kyoo Park, Namwoo Yi, Jaesung Park, Tae Y. Choi, Jin Young Lee, Ahmed Busnaina, and Dongsik Kim

Appl. Phys. Lett. 99, 163702 (2011); http://dx.doi.org/10.1063/1.3652704 (3 pages) | Cited 3 times

Online Publication Date: 19 October 2011

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We demonstrate a strong correlation between denaturation of bovine serum albumin (BSA) and the thermal conductivity k of aqueous solutions of BSA. When denaturation of BSA began, k dropped significantly. These results suggest that k, i.e., the ability of a protein to transport passively applied thermal energy, can be exploited to probe the conformational dynamics of BSA and potentially of other proteins. The technique of protein analysis demonstrated in this work is expected to be useful in micro-total-analysis systems because it is easier to miniaturize and to integrate into a device than is conventional differential scanning calorimetry analysis.
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87.15.H- Dynamics of biomolecules
87.15.N- Properties of solutions of macromolecules
36.20.Ey Conformation (statistics and dynamics)
87.14.E- Proteins

A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

Hee-Jo Lee, Jung-Hyun Lee, and Hyo-Il Jung

Appl. Phys. Lett. 99, 163703 (2011); http://dx.doi.org/10.1063/1.3653959 (3 pages) | Cited 5 times

Online Publication Date: 20 October 2011

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A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are Δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.
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87.80.-y Biophysical techniques (research methods)
84.40.Az Waveguides, transmission lines, striplines

The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli

Shang-Ru Tsai, Tsui-Chin Huang, Chia-Ming Liang, Hsin-Yi Chang, Yi-Tsung Chang, Hsuan-Cheng Huang, Hsueh-Fen Juan, and Si-Chen Lee

Appl. Phys. Lett. 99, 163704 (2011); http://dx.doi.org/10.1063/1.3655031 (3 pages) | Cited 1 time

Online Publication Date: 20 October 2011

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While broad band infrared has a number of biomedical applications, the effects with specific wavelengths on biomolecule remain unclear. In this study, narrow band infrared plasmonic thermal emitters with peak wavelengths from 3.0 to 5.0 μm were developed to irradiate Escherichia coli (E. coli) cultures for 24 h. It was found that with peak wavelengths at 4.0, 4.5, and 5.0 μm, they could promote the growth of cells. Systems biology analyses were performed to investigate the underlying molecular mechanisms. Furthermore, specific wavelengths (4.0-5.0 μm) induced the expression of transporters and enzymes involved in metabolism and respiration, thus stimulating the proliferation of E. coli.
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87.17.Ee Growth and division
87.50.wf Biophysical mechanisms of interaction

Bioinspired ultraviolet reflective photonic structures derived from butterfly wings (Euploea)

Fang Song, Huilan Su, Jianjun Chen, Di Zhang, and Won-Jin Moon

Appl. Phys. Lett. 99, 163705 (2011); http://dx.doi.org/10.1063/1.3653260 (3 pages)

Online Publication Date: 20 October 2011

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Butterfly wings have been demonstrated to have potential applications in various optical devices. For complementarily, we extend them to ultraviolet (UV) reflectors, inspired by the UV reflective photonic structures that have been evolved to satisfy UV communication systems of butterflies. UV reflective photonic structures of butterfly wings were replicated in multiscale, and thus endowed the resultant SnO2 materials with enhanced UV reflection. This biomimetic strategy provides us a universal way towards UV reflectors without changing the chemical compositions. Furthermore, the UV reflection could be potentially tuned by choosing different photonic structures of butterfly wings and other bio-species.
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87.80.Fe Micromanipulation of biological structures
87.85.jf Bio-based materials
87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications

Enhanced endocytosis of nano-curcumin in nasopharyngeal cancer cells: An atomic force microscopy study

R. Prasanth, Greshma Nair, and C. M. Girish

Appl. Phys. Lett. 99, 163706 (2011); http://dx.doi.org/10.1063/1.3653388 (3 pages) | Cited 4 times

Online Publication Date: 21 October 2011

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Recent studies in drug development have shown that curcumin can be a good competent due to its improved anticancer, antioxidant, anti-proliferative, and anti-inflammatory activities. A detailed real time characterization of drug (curcumin)-cell interaction is carried out in human nasopharyngeal cancer cells using atomic force microscopy. Nanocurcumin shows an enhanced uptake over micron sized drugs attributed to the receptor mediated route. Cell membrane stiffness plays a critical role in the drug endocytosis in nasopharyngeal cancer cells.
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87.85.Rs Nanotechnologies-applications
87.16.Uv Active transport processes
87.64.Dz Scanning tunneling and atomic force microscopy
87.19.xj Cancer
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