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4 Jul 2011

Volume 99, Issue 1, Articles (01xxxx)

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Appl. Phys. Lett. 99, 011107 (2011); http://dx.doi.org/10.1063/1.3606505 (3 pages)

Kosei Ueno, Satoaki Takabatake, Ko Onishi, Hiroko Itoh, Yoshiaki Nishijima, and Hiroaki Misawa
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Diagnosis of breast cancer recurrence using a microfluidic device featuring tethered cationic polymers

Jem-Kun Chen, Bing-Jun Bai, and Feng-Chih Chang

Appl. Phys. Lett. 99, 013701 (2011); http://dx.doi.org/10.1063/1.3608239 (3 pages) | Cited 8 times

Online Publication Date: 6 July 2011

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In this study, we grafted pH-responsive poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) onto a Si substrate as the medium in a microfluidic device to detect breast cancer recurrence DNA (bcrDNA584) and a control human genomic DNA (hgDNA528) at extremely low concentrations (down to 0.15 ng/μl). The quantities of these two DNAs obtained through the capture and release from tethered PDMAEMA brushes under pH tuning conditions were sufficient for them to be amplified recognizably, suggesting that this approach could be used in miniaturized lab-on-a-chip cartridges for rapid disease diagnosis.
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87.85.J- Biomaterials
87.14.gk DNA
87.19.xj Cancer
87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

Mineral concentration dependent modulation of mechanical properties of bone-inspired bionanocomposite scaffold

Abhijit Biswas, Timothy C. Ovaert, Constance Slaboch, He Zhao, Ilker S. Bayer, Alexandru S. Biris, and Tao Wang

Appl. Phys. Lett. 99, 013702 (2011); http://dx.doi.org/10.1063/1.3607283 (3 pages) | Cited 1 time

Online Publication Date: 8 July 2011

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We demonstrate tunable mechanical properties of bone-inspired bionanocomposite scaffolds while maintaining the required viscoelasticity. Mechanical properties such as hardness and elastic modulus of the bionanocomposite scaffolds were controlled by varying mineral concentrations of the bioscaffold. In particular, higher calcium and oxygen contents in the bioscaffold resulted in a significant enhancement in hardness and modulus of the bionanocomposite. Moreover, the phosphorous content appeared to be a determining factor in the hardness and mechanical properties of the bionanocomposites. These results open up the possibility of designing new engineered biocompatible nanoscaffolds with desired and tunable biomimetic functions and biomechanical properties with significant potential for advanced bone tissue engineering platforms and bone substitutes.
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87.85.jc Electrical, thermal, and mechanical properties of biological matter
87.85.Rs Nanotechnologies-applications
81.07.-b Nanoscale materials and structures: fabrication and characterization
81.40.Jj Elasticity and anelasticity, stress-strain relations
81.40.Np Fatigue, corrosion fatigue, embrittlement, cracking, fracture, and failure
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