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Applied Physics Letters / Volume 99 / Issue 23 / LASERS, OPTICS, AND OPTOELECTRONICS

Appl. Phys. Lett. 99, 231109 (2011); http://dx.doi.org/10.1063/1.3664345 (3 pages)

Nonlinear-optical brain anatomy by harmonic-generation and coherent Raman microscopy on a compact femtosecond laser platform

Lyubov V. Doronina-Amitonova1,2, Aleksandr A. Lanin1, Olga I. Ivashkina2,3, Marina A. Zots2,3, Andrei B. Fedotov1,2, Konstantin V. Anokhin2,3, and Aleksei M. Zheltikov1,2,4

1Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Russia
2Department of Neuroscience, Kurchatov National Research Center, Moscow, Russia
3P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
4Department of Physics and Astronomy, Texas A&M University, College Station, Texas 77843, USA

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(Received 30 August 2011; accepted 5 November 2011; published online 8 December 2011)

An extended-cavity Cr:forsterite laser is integrated with a photonic-crystal fiber soliton frequency shifter and a periodically poled lithium niobate spectrum compressor for simultaneous harmonic-generation and coherent Raman brain imaging. Adapting the laser beam focusing geometry to the tissue morphology is shown to enable complementarity enhancement in tissue imaging by second- and third-harmonic generation, as well as coherent Raman scattering, facilitating quantitative image analysis.

© 2011 American Institute of Physics

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KEYWORDS and PACS

Keywords

biological tissues, biomedical optical imaging, brain, chromium, holey fibres, laser applications in medicine, lithium compounds, magnesium compounds, optical focusing, optical harmonic generation, optical solitons, photonic crystals, Raman spectra

PACS

  • 87.63.lt

    Laser imaging

  • 42.62.Be

    Biological and medical applications

  • 42.65.Ky

    Frequency conversion; harmonic generation, including higher-order harmonic generation

  • 42.81.Wg

    Other fiber-optical devices

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3664345

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    L. V. Doronina-Amitonova, I. V. Fedotov, O. I. Ivashkina, M. A. Zots, A. B. Fedotov, K. V. Anokhin, and A. M. Zheltikov, Appl. Phys. Lett. 98, 253706 (2011)APPLAB000098000025253706000001.


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